The unacknowledged impact of chronic schistosomiasis
The unacknowledged impact of chronic schistosomiasis
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DOI：
10.1177/1742395307084407
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发表时间：
2008-03-01
期刊：
影响因子：
1.3
通讯作者：
Dangerfield-Chay, Madeline
中科院分区：
文献类型：
--
作者：
King, Charles H.;Dangerfield-Chay, Madeline
目的：总结关于慢性血吸虫病疾病范围的新知识，并检查轻度和重度感染的削弱性负担;概述疾病预防目标，包括目前针对年龄的战略和旨在预防传播的更广泛的方案。通过PUBMED和相关数据库，使用“残疾”和残疾或治疗相关主题词，对2004-2007年的论文进行系统检索。报告进行了独立审查including.Results：68篇论文达到审查目标。这些结果表明，有新的证据表明，寄生虫感染、抗寄生虫炎症与受影响人群的贫血、生长发育迟缓和营养不良风险之间存在因果关系，同时也表明了合并感染加剧与认知发展和工作能力受损之间的因果关系。正式的生活质量评估定义了一个显着的9.5-24%的残疾与最具侵略性的寄生虫物种，血吸虫japonicum.Discussion：血吸虫病是一个严重的，但认识不足的疾病负担，许多发展中国家。感染（而不是感染的强度）应被视为发病率形成的定义特征。感染与长期残疾之间的联系减少了消除农村贫穷的机会。我们对与疟疾有关的疾病负担的认识发生了变化，这意味着让受感染者不接受治疗不再合适，新的控制方法应侧重于预防传播。
Objectives: To summarize new knowledge on the range of disease due to chronic schistosomiasis and examine the debilitating burden of both light and heavy infection; to outline goals of disease prevention, including current age-targeted strategies and more extended programmes aimed at preventing transmission.Methods: A systematic search of 2004-2007 papers via PUBMED and related databases using 'schistosom' and disability-or treatment-related subject headings. Reports were independently reviewed for inclusion.Results: Sixty-eight papers met review objectives. These suggest new evidence for a causative link between schistosome infection, antiparasite inflammation, and risk for anaemia, growth stunting and undernutrition in affected populations, as well as exacerbation of co-infections and impairment of cognitive development and work capacity. Formal quality-of-life assessment defines a significant 9.5-24% disability with the most aggressive schistosome species, Schistosoma japonicum.Discussion: Schistosomiasis represents a serious but under-recognized disease burden for many developing countries. Infection (and not intensity of infection) should be considered the defining feature of morbidity formation. Links between infection and long-term disabilities reduce the chances of combating rural poverty. Changes in our appreciation of schistosomiasis-related disease burden means it is no longer appropriate to leave infected persons untreated, and newer approaches to control should focus on preventing transmission.