Concentration of Smaller High-Density Lipoprotein Particle (HDL-P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA).
Concentration of Smaller High-Density Lipoprotein Particle (HDL-P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA).
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DOI：
10.1161/jaha.115.002977
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发表时间：
2016-05-20
影响因子：
5.4
通讯作者：
Jarvik GP
中科院分区：
文献类型：
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作者：
Kim DS;Li YK;Bell GA;Burt AA;Vaisar T;Hutchins PM;Furlong CE;Otvos JD;Polak JF;Arnan MK;Kaufman JD;McClelland RL;Longstreth WT Jr;Jarvik GP
最近的研究未能建立高密度脂蛋白胆固醇水平（HDL-C）和心血管疾病（CVD）之间的因果关系，将焦点转移到其他HDL指标上。我们以前报道过，更小/更高密度的HDL水平对脑血管疾病有保护作用。本研究旨在确定小+中HDL颗粒浓度（HDL-P）或大HDL-P中的哪一种与不同种族队列中的颈动脉内膜中层增厚（cIMT）更密切相关。在对多种族动脉粥样硬化研究（梅萨）参与者的横断面分析中，我们通过线性回归评估了核磁共振光谱测量的小+中等与大HDL-P与颈总动脉和颈内动脉中测量的cIMT的相关性。校正CVD混杂因素后，低密度脂蛋白胆固醇（LDL-C）、HDL-C和小+中HDL-P与常见的心血管疾病（CVD）呈显著负相关。（系数=−1.46 μm; P=0.00037; n=6512）和内部cIMT（系数=−3.82 μm; P=0.0051; n=6418）进行4次独立检验的Bonferroni校正后（显著性阈值=0.0125; α=0.05/4）。在HDL-C调整前，大HDL-P与cIMT结局显著负相关;然而，在HDL-C调整后，大HDL-P与共同cIMT（系数=1.55 μm; P=0.30; n=6512）和内部cIMT（系数=4.84 μm; P=0.33; n=6418）的相关性减弱。在126名男性的单独样本中，与总HDL-P（r p =0.27; P = 0.0024）和大HDL-P（r p= 0.02; P =0.41）测量相比，小/中HDL-P与对氧磷酶1活性（r p = 0.32; P=0.00023）的相关性更强。小+中HDL-P与cIMT测量值显著负相关。小+中等HDL-P与心脏保护性对氧磷酶1活性的相关性可能反映了导致这一发现的HDL的功能方面。
Recent studies have failed to establish a causal relationship between high‐density lipoprotein cholesterol levels (HDL‐C) and cardiovascular disease (CVD), shifting focus to other HDL measures. We previously reported that smaller/denser HDL levels are protective against cerebrovascular disease. This study sought to determine which of small+medium HDL particle concentration (HDL‐P) or large HDL‐P was more strongly associated with carotid intima‐media thickening (cIMT) in an ethnically diverse cohort. In cross‐sectional analyses of participants from the Multi Ethnic Study of Atherosclerosis (MESA), we evaluated the associations of nuclear magnetic resonance spectroscopy–measured small+medium versus large HDL‐P with cIMT measured in the common and internal carotid arteries, through linear regression. After adjustment for CVD confounders, low‐density lipoprotein cholesterol (LDL‐C), HDL‐C, and small+medium HDL‐P remained significantly and inversely associated with common (coefficient=−1.46 μm; P=0.00037; n=6512) and internal cIMT (coefficient=−3.82 μm; P=0.0051; n=6418) after Bonferroni correction for 4 independent tests (threshold for significance=0.0125; α=0.05/4). Large HDL‐P was significantly and inversely associated with both cIMT outcomes before HDL‐C adjustment; however, after adjustment for HDL‐C, the association of large HDL‐P with both common (coefficient=1.55 μm; P=0.30; n=6512) and internal cIMT (coefficient=4.84 μm; P=0.33; n=6418) was attenuated. In a separate sample of 126 men, small/medium HDL‐P was more strongly correlated with paraoxonase 1 activity (r p=0.32; P=0.00023) as compared to both total HDL‐P (r p=0.27; P=0.0024) and large HDL‐P (r p=0.02; P=0.41) measures. Small+medium HDL‐P is significantly and inversely correlated with cIMT measurements. Correlation of small+medium HDL‐P with cardioprotective paraoxonase 1 activity may reflect a functional aspect of HDL responsible for this finding.