Efficient method for the synthesis of polysubstituted benzenes by one-pot tandem reaction of vinyl malononitriles with nitroolefins.
Efficient method for the synthesis of polysubstituted benzenes by one-pot tandem reaction of vinyl malononitriles with nitroolefins.
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DOI：
10.1021/jo070766i
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发表时间：
2007-06
期刊：
影响因子：
--
通讯作者：
D. Xue;Jie Li;Zun-ting Zhang;Jin-gen Deng
中科院分区：
文献类型：
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作者：
D. Xue;Jie Li;Zun-ting Zhang;Jin-gen Deng
以乙烯基丙二腈与硝基烯烃的乙烯基迈克尔加成为关键步骤，通过串联反应，实现了多取代苯衍生物的一锅法合成。以满意的产率合成了联苯、三联苯等一系列复杂的芳基化合物。
The one-pot synthesis of polysubstituted benzene derivatives was achieved via vinylogous Michael addition of vinyl malononitriles and nitroolefins as the key step and a sequential tandem reaction. A series of complex aryl compounds such as biphenyls and terphenyls can be obtained with satisfactory yields.