Activity and isoenzyme patterns of glycolytic enzymes during perinatal development of rat lung.
Activity and isoenzyme patterns of glycolytic enzymes during perinatal development of rat lung.
复制标题
大鼠肺围产期发育过程中糖酵解酶的活性和同工酶模式。
DOI：
10.1016/0304-4165(85)90257-0
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
L. V. van Golde
中科院分区：
文献类型：
--
作者：
G. Rijksen;G. Staal;M. Streefkerk;A. D. de Vries;J. J. Batenburg;E. Heesbeen;L. V. van Golde
The enzymes hexokinase (EC 2.7.1.1), phosphofructokinase (EC 2.7.1.11), enolase (EC 4.2.1.11) and pyruvate kinase (EC 2.7.1.40) were studied in rat lung during development starting at day 16 of gestation (day-6) until 5 days after birth. During gestation, the activities of hexokinase type II, enolase and pyruvate kinase decreased and reached adult values at birth or shortly thereafter. Hexokinase type I remained relatively constant and the decrease of soluble type II hexokinase was compensated for by an increment of particle-bound hexokinase starting at day 20 of gestation until birth. In contrast, phosphofructokinase activity increased until day 20 of gestation followed by a rapid fall in activity until 2 days after birth. Except for hexokinase no isoenzyme shifts were observed in the period of observation. The results are discussed with respect to the proposed relationship between glycogen breakdown and surfactant synthesis during the perinatal period and suggest a regulatory role for phosphofructokinase in this process.
