κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus
κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus
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DOI：
10.1016/s0304-3940(98)00059-7
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发表时间：
1998-02-20
影响因子：
2.5
通讯作者：
Romano, A
中科院分区：
文献类型：
--
作者：
Freudenthal, R;Locatelli, F;Romano, A
基因表达的调节参与了长期记忆的巩固。目前的结果支持的作用，Rel/NF κ B样激活在这一过程中。在蟹Chasmagnathus，间隔介绍15个或更多的危险刺激诱导长期习惯化（LTH），而没有LTH后，观察到大量的训练600次试验。当一组训练30间隔试验相比，一个被动的控制组和大量的训练组，一个更高水平的特定的Rel/kappa-B样DNA结合活性被发现在脑核提取物。这些结果强烈地表明，在脑中Rel/kappa-B样DNA结合活性的增强与LTH形成特异性相关。(C)1998爱思唯尔科学爱尔兰有限公司
Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/NF kappa-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/kappa-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/kappa-B like DNA-binding activity in the brain is specifically related to LTH formation. (C) 1998 Elsevier Science Ireland Ltd.