Metabolism of Tributyltin by Aquatic Organisms
Metabolism of Tributyltin by Aquatic Organisms
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水生生物对三丁基锡的代谢
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
Richard F. Lee
中科院分区：
文献类型：
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作者：
Richard F. Lee
本章概述了关于海洋动物和植物群对三丁基锡的代谢以及这种代谢与某些观测到的效应之间的关系的工作。鱼类和甲壳类动物有一个依赖细胞色素P-450的活性单加氧酶系统，可将三丁基锡化合物氧化成一系列羟基化衍生物。这些羟基化衍生物通过二相酶系统与硫酸盐或碳水化合物结合，这有助于消除三丁基锡化合物。软体动物细胞色素P-450含量和混合功能加氧酶活性较低，导致TBT的积累和净化速度较慢。在软体动物中观察到的一些三丁基锡化合物效应包括：狭舌腹足类的性畸变;牡蛎的贝壳脱落;贻贝的生长率降低;牡蛎的性别分化、卵子发生和产卵的中断。我认为，这些影响与三丁基锡化合物的缓慢代谢、三丁基锡化合物代谢物与细胞蛋白质的结合以及三丁基锡化合物对解毒酶系统（如细胞色素P-450系统和谷胱甘肽S-转移酶）的抑制有关。三丁基锡化合物和激素有着共同的代谢途径，三丁基锡化合物的许多影响都受到生殖系统的调节。
This chapter summarizes work on the metabolism of tributyltin (TBT) by marine fauna and flora and how this metabolism may relate to some observed effects. Fish and crustaceans have an active cytochrome P-450 dependent monooxygenase system that oxidizes TBT to a series of hydroxylated derivatives. These hydroxylated derivatives are conjugated to sulfate or carbohydrate by phase-two enzyme systems, which facilitates the elimination of TBT. Molluscs have low cytochrome P-450 content and mixed function oxygenase activity, which result in TBT accumulation and slow depuration due to the low rate of TBT metabolism. Some of the TBT effects observed for molluscs include imposex in stenoglossan gastropods; shell thicken ing in oysters; reduced growth rates in mussels; and breakdown of sexual differentiation, oogenesis, and egg production in Ostrea edulis. I suggest that these effects are related to the slow metabolism of TBT, binding of TBT metabolites to cellular proteins, and inhibition of detoxifying enzyme systems (e.g. cytochrome P-450 systems and glutathione S-transferases) by TBT. TBT and hormones share common metabolic pathways, and many effects of TBT are hormonally regulated.
双（三正丁基锡）氧化物对肝细胞色素 P-450 的直接体外影响。
影响因子：
5.8
作者：
Rosenberg,DW;Drummond,GS
通讯作者：
Drummond,GS