The role of GILZ in lipid metabolism and adipocyte biology
The role of GILZ in lipid metabolism and adipocyte biology
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DOI：
10.1016/j.prostaglandins.2022.106668
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Caifeng Xie
中科院分区：
文献类型：
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作者：
Shiyin Chen;Zhen Xiong;Cheng Ma;Bei Zhang;Caifeng Xie
Glucocorticoid-induced leucine zipper (GILZ) is a glucocorticoid-responsive protein and is thought to mediate part of the anti-inflammatory effects of glucocorticoid receptors (GRs). Its role in inflammation and immune responses has been widely studied since its discovery in 1997. Recently, increasing studies showed that GILZ might be involved in the differentiation of preadipocytes and adipogenesis. This review aims to provide readers with the latest updates on the biology of GILZ. The role and regulatory mechanism of GILZ in lipid metabolism and preadipocytes differentiation were summarized. In addition, new insights on the regulatory mechanism of GILZ in adipocyte browning was also discussed, which proposes a novel therapeutic target for lipid metabolic disorders in the future. However, research related to the function and regulatory mechanisms of GILZ in lipid metabolism and adipocyte biology is still in its infancy, and there is still much work needs to be done. • GILZ plays an important role in low-level chronic inflammation with lipid metabolism disorder. • GILZ has a certain effect on adipocytokine signaling pathway. • GILZ exerts opposite effect to glucocorticoids in the regulation of adipocyte differentiation. • GILZ may involve in the regulation of adipocyte browning.
