Concurrent Heroin Use and Correlates among Methadone Maintenance Treatment Clients: A 12-Month Follow-up Study in Guangdong Province, China.
Concurrent Heroin Use and Correlates among Methadone Maintenance Treatment Clients: A 12-Month Follow-up Study in Guangdong Province, China.
复制标题
DOI：
10.3390/ijerph13030305
复制
发表时间：
2016-03-09
影响因子：
--
通讯作者：
Ling L
中科院分区：
文献类型：
--
作者：
Luo X;Zhao P;Gong X;Zhang L;Tang W;Zou X;Chen W;Ling L
目的：评估中国广东省美沙酮维持治疗 (MMT) 患者同时使用海洛因的情况及其相关性。方法：通过结构化问卷收集人口统计和药物使用数据，并从广东 MMT 诊所登记系统获取 MMT 信息。人类免疫缺陷病毒（HIV-）和丙型肝炎病毒（HCV）感染状态和尿液吗啡结果通过实验室测试获得。采用逻辑回归来研究与同时使用海洛因相关的因素。结果：在 6848 名参与者中，75% 的人在开始治疗后的前 12 个月内继续使用海洛因一次以上。同时吸食海洛因与家庭关系不和谐（OR（比值比）= 1.49，95% CI（置信区间）：1.24–1.78）、HIV 阳性（OR = 1.25，95% CI：1.01–1.55）、拥有多个性伴侣（OR = 1.34，95% CI：1.07–1.69）、曾经吸食过静脉注射药物（OR = 0.81，95% CI：0.69–0.95）、维持剂量较高（OR = 1.13，95% CI：1.01–1.28）和 MMT 出席率较差（OR<20% = 1.32，95% CI：1.13–1.53；OR20%– = 1.33，95% CI： 1.14–1.54；OR50%– = 1.69，95% CI：1.44–2.00）。在同时使用海洛因的人中，相同的因素以及年龄较大（OR35– = 1.26，95% CI：1.11–1.43；OR≥45 = 1.63，95% CI：1.30–2.05）和女性（OR = 1.60，95% CI：1.28–2.00）导致海洛因使用频率更高。结论：广东 MMT 参与者同时吸食海洛因的情况很普遍，这凸显出迫切需要针对该人群制定针对性的干预措施和健康教育计划。
Objective: To assess concurrent heroin use and correlates among Methadone Maintenance Treatment (MMT) clients in Guangdong Province, China. Method: Demographic and drug use data were collected with a structured questionnaire, and MMT information was obtained from the MMT clinic registration system in Guangdong. Human immunodeficiency virus (HIV-) and hepatitis C virus (HCV) infected status and urine morphine results were obtained from laboratory tests. Logistic regressions were employed to investigate the factors associated with concurrent heroin use. Results: Among the 6848 participants, 75% continued using heroin more than once during the first 12 months after treatment initiation. Concurrent heroin use was associated with inharmonious family relationship (OR (odds ratio) = 1.49, 95% CI (confidence intervals): 1.24–1.78), HIV positivity (OR = 1.25, 95% CI: 1.01–1.55), having multiple sex partners (OR = 1.34, 95% CI: 1.07–1.69), having ever taken intravenous drugs (OR = 0.81, 95% CI: 0.69–0.95), higher maintenance dose (OR = 1.13, 95% CI: 1.01–1.28) and poorer MMT attendance (OR<20% = 1.32, 95% CI: 1.13–1.53; OR20%– = 1.33, 95% CI: 1.14–1.54; OR50%– = 1.69, 95% CI: 1.44–2.00). Among those who used heroin concurrently, the same factors, and additionally being older (OR35– = 1.26, 95% CI: 1.11–1.43; OR≥45 = 1.63, 95% CI: 1.30–2.05) and female (OR = 1.60, 95% CI: 1.28–2.00), contribute to a greater frequency of heroin use. Conclusions: Concurrent heroin use was prevalent among MMT participants in Guangdong, underscoring the urgent needs for tailored interventions and health education programs for this population.