The role of cytogenetics in early triage of radiation casualties
The role of cytogenetics in early triage of radiation casualties
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DOI：
10.1016/s0969-8043(00)00054-3
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发表时间：
2000-05-01
影响因子：
1.6
通讯作者：
Guerrero-Carbajal, YC
中科院分区：
文献类型：
--
作者：
Lloyd, DC;Edwards, AA;Guerrero-Carbajal, YC
通过染色体分析可以快速作出初步剂量估计，以补充基于临床体征的辐射伤亡的早期分诊。本文描述了一起事故的体外模拟，该事故有多名伤员接受0-8Gy射线的全身或部分照射。面对快速见效的迫切需要，临床分流的确认通常可以通过对每个受试者20个中期进行评分来获得。评分应提高到50个细胞，如果与最初的评估不一致，或有证据表明暴露严重不均匀。(C)2000年由爱思唯尔科学有限公司出版。版权所有。
Preliminary dose estimates by chromosomal analysis can be made rapidly in order to supplement early triage of radiation casualties based on clinical signs. An in vitro simulation of an accident with many casualties receiving whole or partial body exposure in the range 0-8 Gy is described. Faced with an urgent need for rapid results, confirmation of clinical triage can generally be obtained from scoring 20 metaphases per subject. Scoring should be increased to 50 cells where there is disagreement with the initial assessments or evidence of significantly inhomogeneous exposure. (C) 2000 Published by Elsevier Science Ltd. Ail rights reserved.