Comments on the article ‘Defining hormesis’, by EJ Calabrese and LA Baldwin
Comments on the article ‘Defining hormesis’, by EJ Calabrese and LA Baldwin
复制标题
DOI：
10.1191/0960327102ht222oa
复制
发表时间：
2002-02
影响因子：
2.8
通讯作者：
A C Upton
中科院分区：
文献类型：
--
作者：
A C Upton
鉴于生物反应的多样性以及其中许多反应仍不清楚的程度，Calabrese和Baldwin的建议是有道理的，即“兴奋效应”一词应适用于那些以双相剂量-反应关系为特征的适应性反应，而不涉及任何相关的有益或有害影响。辐射诱发突变和染色体畸变的剂量-反应关系是否具有双相性是一个尚待解决的重要问题。
In view of the diversity of biological responses and the extent to which many of them remain poorly elucidated, there is merit in the suggestion by Calabrese and Baldwin that the term ‘hormesis’ should be applicable to those adaptive responses that are characterized by biphasic dose–response relationships, without reference to any associated beneficial or harmful effects. Whether the dose–response relationships for radiation-induced mutations and chromosome aberrations are biphasic in nature is an important question that remains to be resolved.