FMRI visualization of brain activity during a monetary incentive delay task
FMRI visualization of brain activity during a monetary incentive delay task
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DOI：
10.1006/nimg.2000.0593
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发表时间：
2000-07-01
期刊：
影响因子：
5.7
通讯作者：
Hommer, D
中科院分区：
文献类型：
--
作者：
Knutson, B;Westdorp, A;Hommer, D
比较研究表明，纹状体和内侧前脑回路在产生自主神经，内分泌和行为反应的激励。使用血氧水平依赖性功能磁共振成像，我们试图可视化这些区域的功能激活在12个正常志愿者，因为他们预期和响应的金钱激励。对时间序列数据的个体和群体分析都显示，在涉及金钱奖励和惩罚的试验中，纹状体和内侧前脑结构（包括尾状核、尾状核、壳核和内侧前额叶皮层）显著激活。除了这些区域，在涉及惩罚的试验中，组分析显示前扣带回和丘脑的激活灶。这些结果证实了比较研究，其中涉及纹状体和内侧前脑电路的激励驱动的行为的阐述。本报告还介绍了一种新的范式，用于探测人类这种电路的功能完整性。
Comparative studies have implicated striatal and mesial forebrain circuitry in the generation of autonomic, endocrine, and behavioral responses for incentives. Using blood oxygen level-dependent functional magnetic resonance imaging, we sought to visualize functional activation of these regions in 12 normal volunteers as they anticipated and responded for monetary incentives. Both individual and group analyses of time-series data revealed significant activation of striatal and mesial forebrain structures (including insula, caudate, putamen, and mesial prefrontal cortex) during trials involving both monetary rewards and punishments. In addition to these areas, during trials involving punishment, group analysis revealed activation foci in the anterior cingulate and thalamus. These results corroborate comparative studies which implicate striatal and mesial forebrain circuitry in the elaboration of incentive-driven behavior. This report also introduces a new paradigm for probing the functional integrity of this circuitry in humans.