Protein kinase C epsilon: a new target to control inflammation and immune-mediated disorders
Protein kinase C epsilon: a new target to control inflammation and immune-mediated disorders
复制标题
DOI：
10.1016/s1357-2725(03)00210-3
复制
发表时间：
2004-02-01
影响因子：
4
通讯作者：
Willems, F
中科院分区：
文献类型：
--
作者：
Aksoy, E;Goldman, M;Willems, F
最近在理解哺乳动物宿主对微生物入侵的免疫反应的分子基础方面的进展表明，抵抗微生物的第一道防线是由一组种系编码的受体识别病原体相关的分子模式：Toll样受体（TLR）。TLR已被鉴定为病原体识别受体大家族的一部分，其在诱导先天性和适应性免疫中起决定性作用。事实上，T淋巴细胞的活化取决于它们与先前由TLR激动剂如细菌脂多糖（LPS）（TLR-4配体）刺激的树突状细胞的相互作用。新近发现一种新的蛋白激酶C（PKC β）是TLR-4信号通路的重要组成部分，在巨噬细胞和树突状细胞（DC）对LPS的反应中起关键作用。因此，控制PKC β的激酶活性可能是预防或治疗某些微生物源性炎症性疾病的有效策略。(C)2003 Elsevier Ltd.保留所有权利。
Recent advances in understanding the molecular basis for mammalian host immune responses to microbial invasion suggest that the first line of defense against microbes is the recognition of pathogen-associated molecular patterns by a set of germline-encoded receptors: the Toll-like receptors (TLRs). TLRs have been identified as being part of a large family of pathogen-recognition receptors that play a decisive role in the induction of both innate and adaptive immunity. Indeed, activation of T lymphocytes depends on their interaction with dendritic cells previously stimulated by TLR agonists such as bacterial lipopolysaccharide (LPS), a TLR-4 ligand. A novel PKC epsilon (epsilon) was recently found to be a critical component of TLR-4 signaling pathway and thereby to play a key role in macrophage and dendritic cell (DC) activation in response to LPS. Thus, controlling the kinase activity of PKC epsilon might represent an efficient strategy to prevent or treat certain inflammatory disorders of microbial origin. (C) 2003 Elsevier Ltd. All rights reserved.