The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2007.08.019
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发表时间：
2009-05-01
影响因子：
4.2
通讯作者：
de Leon, Mony J.
中科院分区：
文献类型：
--
作者：
Glodzik-Sobanska, Lidia;Pirraglia, Elizabeth;de Leon, Mony J.
虽然脑脊液（CSF）生物标志物可用于预测和诊断阿尔茨海默病，但我们对年龄和ApoE基因型的背景效应的理解是有限的。对78名基于社区的正常志愿者（平均年龄60 ± 10岁，范围36-86）进行了检查，以确定总tau（T-tau）、过度磷酸化tau（P-tau 231）、淀粉样蛋白β（A β 42/A β 40比值）和异前列腺素（IP）的CSF测量值与年龄和ApoE基因型之间的关系。结果显示，对于P-tau 231（β = 1.82; p < 0.05）和IP（β = 1.6; p < 0.05），发现年龄与β 4基因型相互作用。T-tau CSF浓度随年龄增加而增加。P-tau和IP在AD 4携带者中的CSF浓度增加表明早期tau蛋白病和氧化应激可能与AD风险增加有关。数据还表明，T-tau的变化比A β的变化更依赖于年龄。P-tau 231和IP是AD相关神经元损伤的最早标志物的证据有待于纵向研究。(C)2007爱思唯尔公司All rights reserved.
While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60 +/- 10 years, range 36-86) were examined to determine the relationships between CSF measures of total tau (T-tau), hyperphosphorylated tau (P-tau 231), amyloid beta (A beta 42/A beta 40 ratio), and isoprostane (IP) with age and ApoE genotype. The results showed that age by epsilon 4 genotype interactions were found for P-tau231 (beta = 1.82; p < 0.05) and IP (beta = 1.6; p < 0.05). T-tau CSF concentration increased with age. The increasing CSF concentrations of P-tau and IP in epsilon 4 carriers suggest that early tauopathy and oxidative stress may be related to the increased risk for AD. The data also suggest that T-tau changes are more age dependent than A beta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study. (C) 2007 Elsevier Inc. All rights reserved.