Smartphone bioelectronic drug with visual colorimetric sensor and bulk nanoencapsulation optogenetic bacteria for chronic kidney disease theragnostics
Smartphone bioelectronic drug with visual colorimetric sensor and bulk nanoencapsulation optogenetic bacteria for chronic kidney disease theragnostics
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DOI：
10.1016/j.cej.2022.138812
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发表时间：
2022-08
影响因子：
15.1
通讯作者：
Meihui Cui;Wei Ling;Lili Zhang;Yayang Li;Jing Liu;T. Sun;Binglin Ma;Shenjunjie Lu;Huizhuo Pan;Gaoju Pang;Yingying Zhang;Shufang Zhang;Xian Huang;P. Zhao;Duo Liu;Hanjie Wang
中科院分区：
文献类型：
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作者：
Meihui Cui;Wei Ling;Lili Zhang;Yayang Li;Jing Liu;T. Sun;Binglin Ma;Shenjunjie Lu;Huizhuo Pan;Gaoju Pang;Yingying Zhang;Shufang Zhang;Xian Huang;P. Zhao;Duo Liu;Hanjie Wang
床旁检测（POCT）由于其便携式检测方式和快速的医疗决策，已被广泛用于慢性病诊断。然而，传统的POCT技术缺乏快速和精确的治疗手段，偏离了家庭诊断和个性化治疗的综合治疗诊断学系统的要求。在这里，我们提出了一种智能手机控制的，系统级的生物电子药物与可编程的床旁治疗诊断学（POCTH）的慢性肾脏疾病监测。该系统具有基于尿液的比色传感器，用于病理定量和工程细菌，可以产生用于疾病调节的靶向免疫调节剂（IL-10），允许实时，在家慢性疾病诊断和治疗。定制的智能手机应用程序已经开发用于图像捕获、比色分析和无线传输。此外，还制备了一种柔性光电器件，用于与大鼠共形整合和光遗传细菌的无线调制。该系统在生理监测和慢性疾病的个性化诊断方面具有复杂的应用。
Point-of-care testing (POCT) has been widely employed for chronic disease diagnosis due to its portable testing modalities and fast medical decisions. However, conventional POCT techniques lack the means of rapid and precise treatment, deviating from the requirement of an integrated theragnostics system for home diagnosis and personalized therapy. Here, we present a smartphone-controlled, system-level bioelectronic drug with programmable point-of-care theragnostics (POCTH) for chronic kidney disease monitoring. The system features a urine-based colorimetric sensor for pathological quantification and engineered bacteria that can generate targeted immune regulators (IL-10) for disease modulation, allowing real-time, at-home chronic disease diagnosis and treatment. Customized smartphone applications have been developed for image capture, colorimetric analysis, and wireless transmission. Besides, a flexible optoelectronic device has also been fabricated for conformal integration with rats and wireless modulation of optogenetic bacteria. The system leads to sophisticated applications in physiological monitoring and personalized diagnosis of chronic diseases.