Functional alterations in lymphoid tissue induced by adrenal cortical secretion
Functional alterations in lymphoid tissue induced by adrenal cortical secretion
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肾上腺皮质分泌引起的淋巴组织功能改变
DOI：
10.1002/aja.1000770104
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发表时间：
1945
影响因子：
--
通讯作者：
A. White
中科院分区：
文献类型：
--
作者：
T. Dougherty;A. White
作者先前提出的证据表明，从淋巴细胞释放抗体蛋白的速率低于垂体-肾上腺素。在小鼠和家兔皮下注射垂体促肾上腺激素后，淋巴组织发生了如下变化：（1）垂体促肾上腺激素对淋巴细胞的增殖有抑制作用;（2）垂体促肾上腺激素对淋巴细胞的增殖有抑制作用;或各种肾上腺皮质制剂：-（1）退行性变化，在注射后1小时内发生，特征为中小淋巴细胞固缩、淋巴细胞胞质脱落、所有淋巴结构水肿和有丝分裂停止;（2）修复变化，其中网状内皮细胞在6小时后变得特别活跃，有核残余物的吞噬作用，大量的组织细胞发育;（3）恢复性变化，在9小时后开始，其中小鼠的淋巴组织在24小时内再次正常;发生存活淋巴细胞的有丝分裂、网状淋巴细胞的成熟和网状淋巴细胞从网状细胞的分化。在肾上腺切除的动物中，淋巴组织没有发生这些变化，这表明垂体激素通过肾上腺皮质起作用。这表明，增加垂体-肾上腺皮质分泌的各种刺激引起淋巴组织的“意外退化“，正如实验所述，并导致γ球蛋白释放到血液中的增加，抗体与γ球蛋白有关，通过淋巴细胞的细胞质的溶解。正常动物血清γ球蛋白和免疫动物抗体蛋白的释放以及r.e.激活的增加。细胞后肾上腺皮质刺激抛出光的淋巴细胞，r.e.细胞和肾上腺皮质在受试者的正常和病理生理中的作用。E. G.白色.
The authors have previously brought forward evidence suggesting that the rate of release of antibody protein from lymphocytes is under pituitary-adrenal control arid that increased amounts of protein can be detected in the blood when the lymphoid tissues undergo profound histological changes.The present investigation shows that in mice and rabbits the following changes take place in lymphoid tissue after a single subcutaneous injection of pituitary adrenotropic hormone or of various adrenal cortical preparations: -(1) degenerative changes, occurring within an hour of the injection and characterized by pyknosis of the medium and small lymphocytes, shedding of cytoplasm of lymphocytes, oedema of all lymphatic structures and cessation of mitosis; (2) repair changes, in which reticulo-endothelial cells become particularly active after six hours, there is phagocytosis of nuclear remnants and large numbers of histiocytes develop and (3) recovery changes which begin after nine hours and in which the lymphoid tissue in mice is again normal within 24 hours; mitoses of surviving lymphocytes, maturation of reticular lymphocytes and differentiation of reticular lymphocytes from reticular cells occur. These changes in lymphoid tissue do not occur in adrenalectomized animals, indicating that the pituitary hormone acts through the adrenal cortex.It is suggested that a great variety of stimuli which increase pituitary-adrenal cortical secretion produce the " accidental involution " of lymphoid tissue as invoked experimentally and result in increased release into the blood of gamma globulin, with which antibody is associated, by dissolution of the cytoplasm of lymphocytes. Liberation of serum gamma globulin in the normal animal and antibody protein in the immunized animal and the increased activation of r.e. cells following adrenal cortical stimulation throws light on the integration of the role of lymphocytes, r.e. cells and the adrenal cortex in the normal and pathological physiology of the subject.-E. G. WHITE.