Aging of the reproductive system in the male hamster: behavioral and endocrine patterns.
Aging of the reproductive system in the male hamster: behavioral and endocrine patterns.
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雄性仓鼠生殖系统的衰老：行为和内分泌模式。
DOI：
10.1095/biolreprod26.5.791
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发表时间：
1982
影响因子：
3.6
通讯作者：
Turek,FW
中科院分区：
文献类型：
--
作者：
Swanson,LJ;Desjardins,C;Turek,FW
本实验旨在描述老年雄性金仓鼠生殖功能的变化，包括行为和激素的变化，并确定松果体切除术或运动是否会改变老年仓鼠的任何生殖参数。第一次实验分别在4、11、24、31月龄时对雄性进行斩首，记录雄性睾丸和性腺的重量。采集干血测定血清睾酮、促黄体生成素（LH）和促卵泡激素（FSH）水平。单精囊和附睾的重量在31月龄时明显低于24月龄，但在4月龄时不低于青春期后雄鱼。此外，在31个月时，这两种测量值的降低并没有伴随着体重、前列腺腹侧或配对睾丸重量的类似减少。血清LH、FSH和睾酮均未见年龄依赖性下降。14月龄的松果体切除术没有改变24或31月龄时测量的任何变量。在第二个实验中，雄性进行了11次15-mm的测试，以观察其与接受交配的雌性的交配行为。除了第13个月和第23个月外，雄性在12到24个月之间每月进行一次测试。记录了插入和射精的频率，射精和射精的潜伏期以及射精后间隔的长度。每月记录体重和睾丸宽度，并于12、18和24个月通过心脏穿刺检测血清睾酮、LH和FSH水平。有一半的动物可以使用跑步轮，但没有观察到轮子对任何生殖变量的影响。在所有年龄段的男性中，射精的比例保持在80%以上。在射精次数、射精潜伏期和射精后间隔的长度方面，没有年龄依赖性的变化。射精潜伏期逐渐增加，但在雄性20个月后显著增加。睾丸宽度、血清睾酮、LH和FSH水平随年龄无明显变化。结果清楚地表明，雄性金仓鼠的生殖功能，无论是在行为上还是在内分泌环境上，都没有随着年龄的增长而出现严重的下降。尽管射精的潜伏期随着年龄的增长而逐渐增加，但即使是最年长的雄性在与接受交配的雌性配对时也表现出完整的交配行为序列。
The present experiments were designed to characterize changes in reproductive function, both behavioral and hormonal, in the aging male golden hamster, and to determine whether or not pinealectomy or exercise would alter any reproductive parameters in aging hamsters.In the first experiment males were decapitated at 4, 11, 24 and 31 months of age and the weights of the testes and sex accessory glands recorded. Trunk blood was collected for determination of serum levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Although the weights of the single seminal vesicles and epididymis were significantly lower at 31 than at 24 months, they were not less than those of postpubertal males at 4 months. Furthermore, these lower values for the 2 measures at 31 months were not accompanied by similar reductions in body weight, ventral prostate or paired testis weight. No age dependent declines in serum LH, FSH or testosterone were observed. Pinealectomy at 14 months of age did not alter any variable measured at 24 or 31 months of age.In the second experiment males were given 11 15-mm tests for copulatory behavior with receptive females. Males were tested monthly between 12 and 24 months of age, except for Months 13 and 23. The frequency of mounts and intromissions, the latency to intromit and ejaculate, and the length of the postejaculatory interval were recorded. Body weight and testis width were recorded monthly and serum testosterone, LH and FSH levels were determined via cardiac puncture at 12, 18 and 24 months. Half of the animals had access to a running wheel, but no effect of the wheel on any reproductive variable was observed. The percentage of males ejaculating remained above 80% for males at all ages. There were no age dependent changes in the number of intromissions, latency to intromit or the length of the postejaculatory interval. The latency to ejaculate increased gradually but significantly after the males were 20 months old. There were no significant changes in testis width, serum testosterone, LH or FSH levels with age.The results clearly show that no serious decrements in reproductive function occur, either in behavior or in endocrine milieu, with age in the male golden hamster. Although the latency to ejaculate increased gradually with age, even the oldest males exhibited the entire copulatory sequence of behaviors when paired with receptive females.