A framework for self-experimentation in personalized health
A framework for self-experimentation in personalized health
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DOI：
10.1093/jamia/ocv150
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发表时间：
2016-05-01
影响因子：
6.4
通讯作者：
Kientz, Julie A.
中科院分区：
文献类型：
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作者：
Karkar, Ravi;Zia, Jasmine;Kientz, Julie A.
目的 描述一个跨学科和方法论框架，用于将单个案例研究设计应用于个性化健康的自我实验。作者检查了该框架对各种健康状况的适用性，并提出了肠易激综合症 (IBS) 的初步案例研究。方法和材料进行了深入的文献综述以开发该框架，并确定应用该框架的绝对和理想的健康状况要求。作者以 IBS 作为案例研究，开发了移动应用程序原型、故事板和框架流程。作者使用以人为本的设计方法进行了三个焦点小组和在线调查，以评估该框架的可行性。结果 所有 6 名焦点小组参与者都对我们的框架持积极看法，并自愿参与未来的研究。大多数人表示他们会相信结果，因为分析的是他们自己的数据。他们最担心的是混杂因素、无意义的措施以及对触发效应时间的错误假设。调查受访者 (N = 60) 更有可能坚持 8 天与 12 天的研究长度，即使这意味着结果的置信度较低。讨论 在移动应用程序中实施自我实验框架对于 IBS 患者来说似乎是可行的。该框架可能适用于其他健康状况。考虑因素包括向非专家教授自我实验的学习曲线以及实施和定制研究设计所涉及的挑战。结论使用移动技术引导人们通过自我实验来调查健康问题是推进个性化健康的一种可行且有前途的方法。
Objective To describe an interdisciplinary and methodological framework for applying single case study designs to self-experimentation in personalized health. The authors examine the framework's applicability to various health conditions and present an initial case study with irritable bowel syndrome (IBS).Methods and Materials An in-depth literature review was performed to develop the framework and to identify absolute and desired health condition requirements for the application of this framework. The authors developed mobile application prototypes, storyboards, and process flows of the framework using IBS as the case study. The authors conducted three focus groups and an online survey using a human-centered design approach for assessing the framework's feasibility.Results All 6 focus group participants had a positive view about our framework and volunteered to participate in future studies. Most stated they would trust the results because it was their own data being analyzed. They were most concerned about confounds, nonmeaningful measures, and erroneous assumptions on the timing of trigger effects. Survey respondents (N = 60) were more likely to be adherent to an 8-vs 12-day study length even if it meant lower confidence results. Discussion Implementation of the self-experimentation framework in a mobile application appears to be feasible for people with IBS. This framework can likely be applied to other health conditions. Considerations include the learning curve for teaching self-experimentation to non-experts and the challenges involved in operationalizing and customizing study designs.Conclusion Using mobile technology to guide people through self-experimentation to investigate health questions is a feasible and promising approach to advancing personalized health.