Pedigree and genotype errors in the Framingham Heart Study
Pedigree and genotype errors in the Framingham Heart Study
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DOI：
10.1186/1471-2156-4-s1-s41
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发表时间：
2003-12-31
期刊：
影响因子：
2.9
通讯作者：
Almasy, L
中科院分区：
文献类型：
--
作者：
Brush, G;Almasy, L
对来自心脏病研究的家系和基因型数据进行了错误检查。在329个家系中，用PREST程序检测到21个家系的错误，其中16个家系的错误得到解决。然后用SIMWALK 2检测基因分型错误。五孟德尔式的错误，发现以下的系谱校正。双重组错误更常见，有142个被检测到错误的概率为0.25或更高。
The pedigree and genotype data from the Framingham Heart Study were examined for errors. Errors in 21 of 329 pedigrees were detected with the program PREST, and of these the errors in 16 pedigrees were resolved. Genotyping errors were then detected with SIMWALK2. Five Mendelian errors were found following the pedigree corrections. Double-recombinant errors were more common, with 142 being detected at mistyping probabilities of 0.25 or greater.