Epicardial adipose tissue volume is an independent predictor of left ventricular reverse remodeling in patients with non-ischemic cardiomyopathy
Epicardial adipose tissue volume is an independent predictor of left ventricular reverse remodeling in patients with non-ischemic cardiomyopathy
复制标题
心外膜脂肪组织体积是非缺血性心肌病患者左心室逆重构的独立预测因子
DOI：
10.1016/j.ijcard.2022.03.051
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Fukuda D.
中科院分区：
文献类型：
--
作者：
Yamaguchi Y;Shibata A;Yoshida T;Tanihata A;Hayashi H;Kitada R;Ehara S;Izumiya Y;Fukuda D.
BackgroundIn some patients with non-ischemic cardiomyopathy, left ventricular (LV) contraction is improved by optimal medical therapy, leading to LV reverse remodeling (RR). Patients with heart failure with improved ejection fraction and LVRR have a good prognosis, but the factors that predict RR are not fully understood. The relationship between body composition and cardiovascular disease has been reported. The present study aimed to assess the clinical predictors of LVRR in association with body composition.MethodsWe recruited patients who were diagnosed with non-ischemic cardiomyopathy between September 2017 and January 2020. Finally, 89 patients with a reduced LV ejection fraction were enrolled in this prospective study. Body composition, including ectopic fat, was measured in all patients using computed tomography. Echocardiography was performed 6 months after enrollment to evaluate LVRR.ResultsLVRR was observed in 39 patients (43.8%) after 6 months. In terms of the demographic findings, epicardial adipose tissue volume was greater in the LVRR group than in the non-LVRR group (135.2 cm3[SD 128.4 cm3] vs. 88.9 cm3[SD 54.6 cm3];p= 0.040). The Kaplan–Meier analysis demonstrated that adverse cardiac events were significantly less frequent in the LVRR group than in the non-LVRR group (log-rank test,p= 0.013). The multivariate logistic regression analysis identified epicardial adipose tissue volume as an independent predictor of LVRR (odds ratio [OR]: 1.010, 95% confidence interval [CI]: 1.001–1.01;p= 0.036).ConclusionEpicardial adipose tissue volume is an independent predictor of LVRR in patients with non-ischemic cardiomyopathy.
