Development of a new melanoma model in C57BL/6 mice.
Development of a new melanoma model in C57BL/6 mice.
复制标题
在 C57BL/6 小鼠中开发新的黑色素瘤模型。
作者：
J. Berkelhammer;R. Oxenhandler;R. Hook;J. Hennessy
In the present study, we induced melanomas in C57BL/6 mice by a single application of 7,12-dimethylbenz(a)anthracene to the scapular region of 4-day-old mice, followed by twice-weekly applications of croton oil. Of 20 mice treated, melanomas arose in two female littermates. The first melanoma (JB/MS) arose 16 weeks after initiation of treatment, and the second melanoma (JB/RH) arose 23 weeks later. The melanomas maintained their melanotic appearance after s.c. transplantation to normal C57BL/6 mice and metastasized spontaneously in the transplant recipients. To our knowledge, these are the first melanomas to have been induced in C57BL/6 mice since the B16 melanoma arose spontaneously in 1954. We feel that the JB/MS and JB/RH melanomas provide an excellent comparative system for studies done with the B16 melanoma. These melanomas of recent origin will also facilitate the investigation of biological, immunological, and biochemical parameters that influence the growth and metastasis of malignant melanomas.
实验光免疫学：紫外线诱发癌变的免疫学后果。
DOI：
10.1111/1523-1747.ep12479260
发表时间：
1981
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Daynes,RA;Bernhard,EJ;Gurish,MF;Lynch,DH
通讯作者：
Lynch,DH
Cloudman 黑色素瘤细胞的表面蛋白。
影响因子：
4.3
作者：
Nordlund,JJ;Cone,RE;Ackles,A;Gershon,R
通讯作者：
Gershon,R