MRSA surveillance programmes worldwide: moving towards a harmonised international approach
MRSA surveillance programmes worldwide: moving towards a harmonised international approach
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DOI：
10.1016/j.ijantimicag.2022.106538
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发表时间：
2022-03-08
影响因子：
10.8
通讯作者：
Vos, Margreet C.
中科院分区：
文献类型：
--
作者：
Baede, Valerie O.;David, Michael Z.;Vos, Margreet C.
多国耐甲氧西林金黄色葡萄球菌（MRSA）监测规划依赖于国家数据收集结构。本研究旨在了解国家MRSA监测规划的多样性，并提出MRSA监测协调框架。国际抗微生物化疗学会（ISAC） MRSA工作组对MRSA监测计划进行了结构化调查，并组织了一次网络研讨会，讨论这些计划的优势和挑战以及协调的指导方针。已完成的调查涉及16个国家的24个耐甲氧西林金黄色葡萄球菌监测规划。若干国家分别报告了流行病学和微生物监测情况。向临床医生和国家决策者通报情况是监测最常见的目的。在所有规划中都存在血液感染监测。其他侵袭性感染也包括在内。三个国家报告了对MRSA携带的积极监测。方法和报告的抗菌药物敏感性，毒力因子，分子基因分型和流行病学元数据差异很大。目前的MRSA监测规划依赖于异构的数据收集系统，这阻碍了国际流行病学监测和研究。为了协调MRSA监测，我们建议改进微生物学和流行病学数据的整合，实施MRSA分离物收集的中央生物库，除了所有BSI病例外，还包括皮肤和软组织感染病例的代表性样本。英国皇家版权所有(c) 2022由Elsevier Ltd.出版。这是一篇基于CC BY-NC-ND许可的开放获取文章（http://creativecommons.org/licenses/by-nc-nd/4.0/）
A B S T R A C T Multinational surveillance programmes for methicillin-resistant Staphylococcus aureus (MRSA) are dependent on national structures for data collection. This study aimed to capture the diversity of national MRSA surveillance programmes and to propose a framework for harmonisation of MRSA surveillance. The International Society of Antimicrobial Chemotherapy (ISAC) MRSA Working Group conducted a structured survey on MRSA surveillance programmes and organised a webinar to discuss the programmes' strengths and challenges as well as guidelines for harmonisation. Completed surveys represented 24 MRSA surveil-lance programmes in 16 countries. Several countries reported separate epidemiological and microbiolog-ical surveillance. Informing clinicians and national policy-makers were the most common purposes of surveillance. Surveillance of bloodstream infections (BSIs) was present in all programmes. Other invasive infections were often included. Three countries reported active surveillance of MRSA carriage. Method-ology and reporting of antimicrobial susceptibility, virulence factors, molecular genotyping and epidemi-ological metadata varied greatly. Current MRSA surveillance programmes rely upon heterogeneous data collection systems, which hampers international epidemiological monitoring and research. To harmonise MRSA surveillance, we suggest improving the integration of microbiological and epidemiological data, im-plementation of central biobanks for MRSA isolate collection, and inclusion of a representative sample of skin and soft-tissue infection cases in addition to all BSI cases.Crown Copyright (c) 2022 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )