A mechanism of synergistic lung damage by ozone and a respirable aerosol.
A mechanism of synergistic lung damage by ozone and a respirable aerosol.
复制标题
臭氧和可吸入气溶胶协同肺损伤的机制。
DOI：
10.3109/01902148409087915
复制
发表时间：
1984
影响因子：
1.7
通讯作者：
Daniel P.Y. Chang
中科院分区：
文献类型：
--
作者：
D. Hyde;Daniel P.Y. Chang
以前在大鼠受控暴露于这些物质的过程中观察到氧化剂空气污染物臭氧或二氧化氮与可吸入大小的硫酸铵气溶胶之间迄今为止意想不到的协同作用。在本文中，我们研究的生化和形态学的变化，大鼠暴露于臭氧（0.64-0.96 ppm），有或没有伴随的气溶胶（约1微米质量中值空气动力学直径）的硫酸铵（5毫克/立方米）的3，7或14天。暴露于污染物混合物3天后，大鼠肺巨噬细胞和巨噬细胞前体（单核细胞）增加2至3倍，成纤维细胞增加2倍，表观胶原蛋白合成率增加2.5倍，成纤维细胞增加2倍，表观胶原蛋白合成率增加2.5倍，与单独暴露于臭氧的动物的值相比。持续暴露于单独的臭氧中7或14天，似乎模拟了污染物混合物3天的变化。每个肺的病变总数是相同的臭氧暴露和不伴随气溶胶;病变较大的大鼠暴露于臭氧加硫酸铵的肺。基于这些研究结果和文献回顾，臭氧气溶胶协同作用的机制提出。我们认为，由氧化剂（如臭氧或二氧化氮）与肺内分子相互作用产生的自由基的寿命会因吸入可吸入气雾剂引起的局部pH值变化或局部硫酸盐浓度变化（或两者）而增加。
A hitherto unexpected synergism between the oxidant air pollutants ozone or nitrogen dioxide and a respirable-sized aerosol of ammonium sulfate was previously observed during controlled exposures of rats to these substances. In this paper we examine biochemical and morphometric changes in lungs of rats exposed for 3, 7, or 14 days to ozone (0.64-0.96 ppm), with or without an accompanying aerosol (approximately 1 micrometer mass median aerodynamic diameter) of ammonium sulfate (5 mg/m3). After 3 days of exposure to the mixture of pollutants, rat lung macrophage and macrophage precursors (monocytes) were increased 2- to 3-fold, fibroblasts were increased 2-fold, and apparent collagen synthesis rates were increased 2.5-fold, fibroblasts were increased 2-fold, and apparent collagen synthesis rates were increased 2.5-fold, as compared with values from animals exposed to ozone alone. Continued exposure to ozone alone for 7 or 14 days seemed to mimic changes seen at 3 days with the mixture of pollutants. Total number of lesions per lung was the same for ozone exposure with and without accompanying aerosol; lesions were larger in lungs of rats exposed to ozone plus ammonium sulfate. Based on these findings and a review of the literature, a mechanism for ozone-aerosol synergism is proposed. We suggest that the lifetime of free radicals arising from interaction of oxidants such as ozone or nitrogen dioxide with molecules within the lung is increased by either local pH changes or changes in the local sulfate concentration (or both) caused by inhalation of the respirable aerosol.
仓鼠博莱霉素诱导的肺纤维化发展过程中浸润性细胞变化的形态测量估计。
DOI：
--
发表时间：
1983
期刊：
The American journal of pathology
影响因子：
--
作者：
Chandler,DB;Hyde,DM;Giri,SN
通讯作者：
Giri,SN