Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands.
Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands.
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DOI：
10.1016/j.pbiomolbio.2006.04.001
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发表时间：
2007-07
影响因子：
3.8
通讯作者：
Lai-Hua Xie;S. John;B. Ribalet;J. Weiss
中科院分区：
文献类型：
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作者：
Lai-Hua Xie;S. John;B. Ribalet;J. Weiss
所有向内纠偏钾通道的成员（Kir1-7）都受膜磷脂，磷脂酰肌醇-4,5-二磷酸（PIP2）的调节。有些还受到其他调节因子或配体的调节，如ATP和g蛋白，这使它们有了共同的名称，如ATP敏感钾（KATP）通道和g蛋白门控钾通道。其他非特异性调节剂包括多胺、激酶、pH和Na+离子。最近的研究表明，pip2与其他调节因子协同作用，调节Kir通道。在这里，我们回顾了pip2和辅助因子如何调节Kir通道的每个亚族中的通道活动。
All members of the inwardly rectifying potassium channels (Kir1-7) are regulated by the membrane phospholipid, phosphatidylinosital-4,5-bisphosphate (PIP2). Some are also modulated by other regulatory factors or ligands such as ATP and G-proteins, which give them their common names, such as the ATP sensitive potassium (KATP) channel and the G-protein gated potassium channel. Other more non-specific regulators include polyamines, kinases, pH and Na+ions. Recent studies have demonstrated that PIP2acts cooperatively with other regulatory factors to modulate Kir channels. Here we review how PIP2and co-factors modulate channel activities in each subfamily of the Kir channels.