Serotonin and human information processing: an electromyographic study of the effects of fluvoxamine on choice reaction time
Serotonin and human information processing: an electromyographic study of the effects of fluvoxamine on choice reaction time
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血清素和人类信息处理：氟伏沙明对选择反应时间影响的肌电图研究
DOI：
10.1016/s0304-3940(99)00231-1
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发表时间：
1999
影响因子：
2.5
通讯作者：
C. Possamaï
中科院分区：
文献类型：
--
作者：
P. Rihet;T. Hasbroucq;O. Blin;C. Possamaï
先前的研究表明，氟伏沙明，一种5-羟色胺再摄取的抑制剂，缩短了选择反应时间。本研究旨在探讨这种影响，通过使用两种互补的方法：（i）斯滕贝格的附加因子法，和（ii）分析的肌电活动的原动机。8名健康受试者接受单次口服剂量的氟伏沙明（100 mg）或安慰剂参加了选择反应时间实验，其中操纵命令信号强度，刺激-反应映射和反应库。重复了以前的结果。此外，研究表明，氟伏沙明缩短了原动机激活和明显反应之间的间隔。这支持了先前研究中提出的假设，即氟伏沙明影响运动过程。这种影响的可能机制进行了讨论。
Previous studies have shown that fluvoxamine, an inhibitor of serotonin reuptake, shortens choice reaction time. The present study, was intended to explore this effect by using two complementary approaches: (i) Sternberg's additive factor method, and (ii) the analysis of the electromyographic activity of a prime mover. Eight healthy subjects who received either a single oral dose of fluvoxamine (100 mg) or a placebo participated in a choice reaction time experiment in which imperative signal intensity, stimulus-response mapping, and response repertoire were manipulated. Previous results were replicated. Moreover, it was shown that fluvoxamine shortens the interval between prime mover activation and overt response. This supports the hypothesis proposed in a previous study that fluvoxamine affects motor processes. A possible mechanism of this effect is discussed.