Gray matter decrease in patients with chronic tension type headache
Gray matter decrease in patients with chronic tension type headache
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DOI：
10.1212/01.wnl.0000183067.94400.80
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发表时间：
2005-11-08
期刊：
影响因子：
9.9
通讯作者：
May, A
中科院分区：
文献类型：
--
作者：
Schmidt-Wilcke, T;Leinisch, E;May, A
应用MRI和体素形态计量学方法，对20例慢性紧张型头痛(CTTH)患者和20例药物滥用头痛患者进行研究，并与40例无头痛病史的对照组进行比较。只有CTTH患者在已知涉及疼痛处理的区域显示出明显的灰质减少。这一发现表明，这些变化是CTTH特有的，而不是对慢性头痛或时序化本身的反应。
Using MRI and voxel-based morphometry, the authors investigated 20 patients with chronic tension type headache (CTTH) and 20 patients with medication-overuse headache and compared them to 40 controls with no headache history. Only patients with CTTH demonstrated a significant gray matter decrease in regions known to be involved in pain processing. The finding implies that the alterations are specific to CTTH rather than a response to chronic head pain or chronification per se.