SENSITIVITY OF INSULIN-SECRETION TO FEEDBACK INHIBITION BY HYPERINSULINEMIA
SENSITIVITY OF INSULIN-SECRETION TO FEEDBACK INHIBITION BY HYPERINSULINEMIA
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DOI：
10.1530/acta.0.0980081
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
FABER, OK
中科院分区：
文献类型：
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作者：
DEFRONZO, RA;BINDER, C;FABER, OK
在 15 名接受静脉注射的正常受试者中检查了胰岛素抑制自身分泌的能力。以每分钟 0.25、0.50、1.0、5.0 或 10.0 mU/kg 的剂量输注胰岛素 2 小时。输注期间达到的动脉血浆胰岛素浓度分为3个高胰岛素血症水平：35.+-。 1（平均值 .+-. 平均值的标准误差），87 .+-. 15 和 828 .+-。 210.mu.U/ml。通过可变葡萄糖输注将血浆葡萄糖浓度保持在基础水平恒定。在高胰岛素血症期间，所有受试者的空腹 C 肽（0.29.+-.0.02 pmol/ml）显着下降，并达到 0.19.+- 的浓度。 60 分钟时为 0.03 pmol/ml，0.14 .+/-。开始胰岛素输注后 120 分钟为 0.03。 C 肽反应与输注剂量和稳态血浆胰岛素浓度无关。根据C肽测量评估的基础胰岛素分泌受到血浆胰岛素浓度小幅(24.+-.3.mu.U/ml)生理性升高的抑制，与血浆葡萄糖的变化无关，并且血浆胰岛素的超生理性或什至药理学性升高不会导致内源性胰岛素分泌进一步减少，超过轻度高胰岛素血症所实现的水平。
The ability of insulin to inhibit its own secretion was examined in 15 normal subjects given an i.v. infusion of insulin in a dose of 0.25, 0.50, 1.0, 5.0 or 10.0 mU/kg per min for 2 h. Arterial plasma insulin concentration achieved during the infusion segregated into 3 levels of hyperinsulinemia: 35 .+-. 1 (mean .+-. standard error of the mean), 87 .+-. 15 and 828 .+-. 210 .mu.U/ml. Plasma glucose concentration was kept constant at the basal level by a variable glucose infusion. Fasting C-peptide (0.29 .+-. 0.02 pmol/ml) fell significantly in all subjects during hyperinsulinemia and reached a concentration of 0.19 .+-. 0.03 pmol/ml at 60 min and 0.14 .+-. 0.03 at 120 min after the start of the insulin infusion. The C-peptide response was not related to the infusion dose nor to the steady state plasma insulin concentration. Basal insulin secretion as evaluated from C-peptide measurements is inhibited by small (24 .+-. 3 .mu.U/ml) physiological elevations in plasma insulin concentration independent of changes in plasma glucose, and supraphysiological or even pharmacological elevations in plasma insulin do not result in a further decrease in endogenous insulin secretion above that achieved with mild hyperinsulinemia.