Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides
Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides
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DOI：
10.1128/aac.01080-10
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Barron, Annelise E.
中科院分区：
文献类型：
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作者：
Chongsiriwatana, Nathaniel P.;Miller, Tyler M.;Barron, Annelise E.
我们报告了烷基化的聚-N-取代甘氨酸（类肽）模拟抗菌脂肽的烷基尾巴范围从5到13个碳的创建。在几种情况下，烷基化显著提高了类肽的选择性，而不损失抗微生物效力。使用这种技术，我们合成了一种抗菌肽只有5个单体的长度与选择性，广谱的抗菌活性，如以前报道的十二聚体类肽和抗菌肽pexiganan有效。
We report the creation of alkylated poly-N-substituted glycine (peptoid) mimics of antimicrobial lipopeptides with alkyl tails ranging from 5 to 13 carbons. In several cases, alkylation significantly improved the selectivity of the peptoids with no loss in antimicrobial potency. Using this technique, we synthesized an antimicrobial peptoid only 5 monomers in length with selective, broad-spectrum antimicrobial activity as potent as previously reported dodecameric peptoids and the antimicrobial peptide pexiganan.