Dopamine in amygdala gates limbic processing of aversive stimuli in humans
Dopamine in amygdala gates limbic processing of aversive stimuli in humans
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DOI：
10.1038/nn.2222
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发表时间：
2008-12-01
影响因子：
25
通讯作者：
Heinz, Andreas
中科院分区：
文献类型：
--
作者：
Kienast, Thorsten;Hariri, Ahmad R.;Heinz, Andreas
Dopamine is released under stress and modulates processing of aversive stimuli. We found that dopamine storage capacity in human amygdala, measured with 6-[F-18]fluoro-L-DOPA positron emission tomography, was positively correlated with functional magnetic resonance imaging blood oxygen level dependent signal changes in amygdala and dorsal anterior cingulate cortex that were evoked by aversive stimuli. Furthermore, functional connectivity between these two regions was inversely related to trait anxiety. Our results suggest that individual dopamine storage capacity in amygdala subserves modulation of emotional processing in amygdala and dorsal cingulate, thereby contributing to individual differences in anxious temperament.
