Prospective analysis of gender-related characteristics in relation to cardiovascular disease
Prospective analysis of gender-related characteristics in relation to cardiovascular disease
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DOI：
10.1136/heartjnl-2021-320414
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发表时间：
2022-02-23
期刊：
影响因子：
5.7
通讯作者：
van Valkengoed, Irene G. M.
中科院分区：
文献类型：
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作者：
Bolijn, Renee;Kunst, Anton E.;van Valkengoed, Irene G. M.
目的心血管疾病（CVD）的男女发病率差异已被广泛报道。除了与性别有关的（生物）特征之外，与性别有关的（社会文化）特征也可以部分解释这些差异是如何产生的。在这项探索性研究中，我们研究了选定的性别相关特征和CVD发病率之间的关联。方法我们将18058名无CVD参与者的基线数据与基于2013-2018年荷兰统计局住院和死亡记录的CVD发病率数据联系起来，这些参与者来自城市环境研究（荷兰阿姆斯特丹）中基于人群的多种族健康生活。使用考克斯回归分析，我们研究了花在家务劳动上的时间，做家庭维修，主要收入者的地位，就业类型，在男性占主导地位或女性占主导地位的职业和情感支持的愿望与CVD发病率的关联，按性别分层。分析根据年龄、种族和社会经济地位进行调整。结果在男性中，与性别相关的特征与较高的CVD发病率无关。在女性中，与全职工作者相比，家庭主妇患CVD的风险更高（HR 2.34，95% CI 1.35至4.04），而那些花中等时间从事家务工作的人患CVD的风险低于那些花很少时间的人（HR 0.56，95% CI 0.34至0.95）。结论虽然我们没有发现证据表明性别相关特征与男性CVD发病率之间存在关联，但家庭主妇和中等时间的家务劳动似乎与女性CVD发病率相关。因此，关注与性别有关的特征可能在未来有助于确定可能受益于额外预防战略的亚组。
Objective Differences in cardiovascular disease (CVD) incidence between men and women have been widely reported. Next to sex-related (biological) characteristics, gender-related (sociocultural) characteristics may partly explain how these differences arise. In this exploratory study, we examined the associations between selected gender-related characteristics and CVD incidence. Methods We linked baseline data of 18 058 participants without CVD from the population-based, multiethnic HEalthy LIfe in an Urban Setting study (Amsterdam, the Netherlands) to CVD incidence data, based on hospital admission and death records from Statistics Netherlands in 2013-2018. Using Cox regression analyses, we studied associations of time spent on household work, doing home repairs, primary earner status, type of employment, working in a male-dominated or female-dominated occupation and desire for emotional support with CVD incidence, stratified by sex. Analyses were adjusted for age, ethnicity and socioeconomic status. Results In men, gender-related characteristics were not associated with higher CVD incidence. In women, homemakers had a higher hazard for CVD compared with full-time workers (HR 2.34, 95% CI 1.35 to 4.04), whereas those spending a moderate amount of time on household work had a lower hazard for CVD than those spending little time (HR 0.56, 95% CI 0.34 to 0.95). Conclusion Although we found no evidence for associations between gender-related characteristics and CVD incidence in men, being the homemaker and moderate time spent on household work appeared to be associated with CVD incidence in women. Thus, attention to gender-related characteristics might in future help to identify subgroups that may benefit from additional prevention strategies.