Long-term remission of malignant brain tumors after intracranial infection: A report of four cases
Long-term remission of malignant brain tumors after intracranial infection: A report of four cases
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DOI：
10.1097/00006123-199903000-00110
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发表时间：
1999-03-01
期刊：
影响因子：
4.8
通讯作者：
Perkins, E
中科院分区：
文献类型：
--
作者：
Bowles, AP;Perkins, E
目的：本报告描述了4例恶性脑肿瘤患者，其消退或治愈似乎与细菌感染有关。方法：对4例临床病例进行分析，并对文献进行回顾，得出了有关细菌感染特性的实验和临床数据的综合体。结果：尽管已经提出了细菌的直接溶瘤作用，但强调了对肿瘤抑制的免疫佐剂反应。在我们的一个病人中，在初次手术时观察到大量粒细胞和淋巴细胞浸润到肿瘤中，这表明自发免疫反应已经开始。此外，在另外两名患者中，肿瘤侵袭与不直接接触肿瘤的细菌过程有关。在所描述的3例病例中，从微生物培养物中回收了产气肠杆菌。这种生物的存在是否是巧合，或者这种生物是否在肿瘤防御中起着重要的作用是未知的，但是，一个特定的交叉反应的免疫攻击的肿瘤suggested.CONCLUSION：结合相关文献回顾的情况下提出的历史支持的概念，微生物感染可能会影响免疫反应，在脑肿瘤防御。
OBJECTIVE: This report describes four patients with malignant brain tumors in whom regression or cure seems to be related to infection with bacteria.METHODS: An analysis of the four clinical cases reported and a review of the literature produced a comprehensive body of both experimental and clinical data concerning the antineoplastic properties of bacteria.RESULTS: Although direct oncolytic effects from bacteria have been suggested, immune adjuvant responses to tumor suppression are emphasized. In one of our patients, infiltration of numerous granulocytes and lymphocytes into the tumor at the time of initial surgery was observed, suggesting that a spontaneous immune reaction had begun. Also, in two other patients, tumor aggression occurred in association with a bacterial process that was not in direct contact with the tumor. In three of the cases described, Enterobacter aerogenes was recovered from the microbial cultures. Whether the presence of this organism was coincidental or whether this organism plays an important role in tumor defense is not known; however, a specific cross-reactive immunological attack to the tumor is suggested.CONCLUSION: The case histories presented in conjunction with the relevant literature reviewed support the concept that microbial infections may influence immune responses in brain tumor defense.