THE ROLE OF PROSTAGLANDINS IN NEUROENDOCRINE JUNCTIONS - STUDIES IN THE PINEAL-GLAND AND THE HYPOTHALAMUS
THE ROLE OF PROSTAGLANDINS IN NEUROENDOCRINE JUNCTIONS - STUDIES IN THE PINEAL-GLAND AND THE HYPOTHALAMUS
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DOI：
10.1159/000123452
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发表时间：
1983-01-01
影响因子：
4.1
通讯作者：
RITTA, MN
中科院分区：
文献类型：
--
作者：
CARDINALI, DP;RITTA, MN
This article discusses current experimental evidence indicating a role for prostaglandins (PGs) in pineal and median eminence neuroendocrine junctions. Both tissues release PGs, particularly of the E series, upon exposure to norepinephrine (NE) and through α-adrenoceptors. Exposure of pineal and median eminence explants to nanomolar concentrations of PGE2 augments melatonin and GnRH release, respectively. In the pineal gland, this effect appears to be linked to the stimulation of adenylate cyclase. Both in vivo and in vitro PG synthesis inhibitors impair the hormone release elicited by NE. In the pineal gland, PGE2 also constitutes a trans-synaptic negative signal for NE release. PGs receptors are present in pineal and hypothalamic membranes.
