Amitriptyline plays important roles in modifying the ovarian morphology and improving its functions in rats with estradiol valerate-induced polycystic ovary
Amitriptyline plays important roles in modifying the ovarian morphology and improving its functions in rats with estradiol valerate-induced polycystic ovary
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阿米替林对戊酸雌二醇致多囊卵巢大鼠卵巢形态的改变和功能的改善具有重要作用
DOI：
10.1007/s12272-015-0573-z
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发表时间：
2017
影响因子：
6.7
通讯作者：
S. Cui
中科院分区：
文献类型：
--
作者：
Xinqiang Li;Shufen Wang;Li Zhang;Lei Zhang;Jiali Liu;Hao;K. Gou;S. Cui
以前的研究表明，抑郁症在多囊卵巢综合征（PCOS）女性中更为普遍。在这项研究中，我们的目的是确定阿米替林（AMT），一种抗抑郁药，是否在预防PCOS中发挥作用。结果表明，AMT修饰卵巢形态能改善戊酸雌二醇（EV）诱导的多囊卵巢（PCO）小鼠的卵巢功能和发情周期。AMT可使EV诱发的PCO大鼠血清雌二醇（E2）、睾酮（T）和孕酮（P4）水平恢复正常，并升高促黄体生成素（LH）水平。在EV或AMT治疗的大鼠中未观察到卵泡刺激素（FSH）水平的显著变化。去甲肾上腺素（NE）水平的恢复在EV诱导的PCO大鼠。AMT还改变了EV诱导的PCO中类固醇生成基因和β 2-肾上腺素受体（β 2-AR）的表达水平。我们的数据显示，AMT改善卵巢形态，并改变卵巢β 2-AR和类固醇生成基因的表达在EV诱导的大鼠PCO。我们的数据为AMT被认为是预防和治疗PCOS沿着抑郁症的候选药物的假设提供了支持。
Previous studies demonstrated that depression is more prevalent in women with polycystic ovary syndrome (PCOS). In this study, we aimed to determine whether amitriptyline (AMT), an antidepressant drug, plays a role in preventing PCOS. The results showed that AMT modified ovarian morphology improved the ovarian functions and estrus cycle in estradiol valerate (EV)-induced polycystic ovary (PCO). AMT restored the levels of estradiol (E2), testosterone (T) and progesterone (P4) to normal, and elevated the level of luteinizing hormone (LH) in EV-induced PCO. No significant changes in follicle stimulating hormone (FSH) levels were observed in rats with EV or AMT treatment. The restoration of norepinephrine (NE) level was detected in rats with EV-induced PCO. AMT also altered the expression levels of steroidogenesis genes and beta2-adrenoceptor (beta2-AR) in EV-induced PCO. Our data revealed that AMT improves the ovarian morphology and modifies ovarian expression of beta2-AR and steroidogenesis genes in rats with EV-induced rat PCO. Our data provide support for the hypothesis that AMT is considered as a candidate drug for preventing and treating PCOS along with depression.
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新型 α-1D 肾上腺素受体对血管平滑肌收缩的具体贡献。
DOI：
--
发表时间：
1995
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Piascik,MT;Guarino,RD;Smith,MS;Soltis,EE;SaussyJr,DL;Perez,DM
通讯作者：
Perez,DM
α1-肾上腺素受体亚型和清醒大鼠外周血流动力学的调节。
影响因子：
5
作者：
Piascik,MT;Kusiak,JW;Barron,KW
通讯作者：
Barron,KW
影响因子：
4.8
作者：
A. Barria;V. Leyton;S. Ojeda;H. Lara
通讯作者：
A. Barria;V. Leyton;S. Ojeda;H. Lara
影响因子：
--
作者：
D. Tomić;K. Miller;H. Kenny;T. Woodruff;P. Hoyer;J. Flaws
通讯作者：
D. Tomić;K. Miller;H. Kenny;T. Woodruff;P. Hoyer;J. Flaws
影响因子：
4.8
作者：
AGUADO, LI;PETROVIC, SL;OJEDA, SR
通讯作者：
OJEDA, SR