PTP1B, A Potential Target of Type 2 Diabetes Mellitus
PTP1B, A Potential Target of Type 2 Diabetes Mellitus
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DOI：
10.4172/2168-9547.1000174
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发表时间：
2016-09
影响因子：
1.2
通讯作者：
Wei Zou
中科院分区：
文献类型：
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作者：
Wei Zou
糖尿病是常见的代谢性疾病之一，主要分为两种类型，1型糖尿病和2型糖尿病。胰岛素抵抗是2型糖尿病的主要表现，与某些基因突变、遗传、肥胖等有关，蛋白酪氨酸磷酸酶1B（Protein-tyrosine phosphatase 1B，PTP 1B）作为胰岛素信号通路的负调控因子，在肥胖、2型糖尿病等代谢性疾病中发挥重要作用。大量的临床和基础研究表明，PTP 1B的高表达可诱导胰岛素抵抗。PTP 1B是治疗2型糖尿病的有效靶点。本文就PTP 1B的组成及其在2型糖尿病胰岛素信号转导中的作用作一综述。本文还对PTP 1B抑制剂在2型糖尿病治疗中的研究进展进行了综述。
Diabetes is one of the common metabolic diseases, mainly divided into two types, type 1 diabetes mellitus and type 2 diabetes mellitus. Insulin resistance is the main performance of type 2 diabetes mellitus which are relative to some gene mutation, genetics, obesity and so on. Protein-tyrosine phosphatase 1B (PTP1B) plays an important role as a negative regulator in insulin signaling pathways that are implicated in metabolic diseases such as obesity and type 2 diabetes. Many evidences from clinical and basic researches show that the high expression of PTP1B induces insulin resistance. It appears that PTP1B is an effective target for the treatment of type 2 diabetes mellitus. In this review, we briefly introduce composition of PTP1B and the role of PTP1B in insulin signaling of type 2 diabetes mellitus. We also summarized recent research progress of PTP1B inhibitors used in therapy of type 2 diabetes mellitus.