Exploring the Complexity-Generating Features of the Pauson-Khand Reaction from a Synthetic Perspective
Exploring the Complexity-Generating Features of the Pauson-Khand Reaction from a Synthetic Perspective
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DOI：
10.1002/ejoc.201600123
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发表时间：
2016-05-01
影响因子：
2.8
通讯作者：
Yang, Zhen
中科院分区：
文献类型：
--
作者：
Shi, Lili;Yang, Zhen
Pauson-Khand反应（PKR）用于从烯烃、炔和一氧化碳通过多米诺骨牌键结构序列构建环戊酮骨架。这篇微评论涵盖了PKR在过去10年作者实验室中一系列结构具有挑战性的天然产物的全合成中的合成应用，漂亮地探索了PKR的复杂性生成特征。这些全合成成功的关键是PKR的实现，以获得含有许多立体中心的复杂靶分子。
The Pauson-Khand reaction (PKR) is used to construct a cyclopentenone framework from an alkene, an alkyne, and carbon monoxide, through a domino sequence of bond constructions. This microreview covers the synthetic application of the PKR in the total synthesis of a collection of structurally challenging natural products in the authors' laboratory over the past 10 years, beautifully exploring the complexity-generating features of the PKR. Key to the success of these total syntheses is the implementation of the PKR to access complex target molecules containing numerous stereocenters.