RNA aptamers for AMPA receptors.
RNA aptamers for AMPA receptors.
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DOI：
10.1016/j.neuropharm.2021.108761
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发表时间：
2021-11-01
影响因子：
4.7
通讯作者：
Niu, Li
中科院分区：
文献类型：
--
作者：
Huang, Zhen;Niu, Li
RNA aptamers are single-stranded RNA molecules, and they are selected against a target of interest so that they can bind to and modulate the activity of the target, such as inhibiting the target activity, with high potency and selectivity. Antagonists, such as RNA aptamers, acting on AMPA receptors, a major subtype of ionotropic glutamate receptors, are potential drug candidates for treatment of a number of CNS diseases that involve excessive receptor activation and/or elevated receptor expression. Here we review the approach to discover RNA aptamers targeting AMPA receptors from a random sequence library (~1014 sequences) through a process called systematic evolution of ligands by exponential enrichment (SELEX). As compared with small-molecule compounds, RNA aptamers are a new class of regulatory agents with interesting and desirable pharmacological properties. Some AMPA receptor aptamers we have developed are presented in this review. The promises and challenges of translating RNA aptamers into potential drugs and treatment options are also discussed.
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影响因子：
7.3
作者：
BRIDGES, RJ;STANLEY, MS;CHAMBERLIN, AR
通讯作者：
CHAMBERLIN, AR
影响因子：
7.3
作者：
Downing, SS;Lee, YT;Gibbs, TT
通讯作者：
Gibbs, TT
DOI：
10.1089/108729002761381276
发表时间：
2002-10-01
期刊：
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT
影响因子：
--
作者：
Dass, CR;Saravolac, EG;Sun, LQ
通讯作者：
Sun, LQ
影响因子：
64.8
作者：
CURTIS, DR;PHILLIS, JW;WATKINS, JC
通讯作者：
WATKINS, JC
DOI：
10.1038/nsb0298-133
发表时间：
1998-02-01
期刊：
NATURE STRUCTURAL BIOLOGY
影响因子：
--
作者：
Convery, MA;Rowsell, S;Stockley, PG
通讯作者：
Stockley, PG