Abnormal retinal function associated with isotretinoin therapy for acne.
Abnormal retinal function associated with isotretinoin therapy for acne.
复制标题
与异维A酸治疗痤疮相关的视网膜功能异常。
DOI：
10.1001/archopht.1986.01050180065031
复制
发表时间：
1986
影响因子：
--
通讯作者：
William J. Cunningham
中科院分区：
文献类型：
--
作者：
R. Weleber;S. Denman;Jon M. Hanifin;William J. Cunningham
50名接受异维A酸（1 mg/kg/天）治疗囊性痤疮的患者中，有3名抱怨夜间视力不佳和/或对强光过度敏感。在仍然接受药物或之后不久，发现两名患者有异常的暗适应曲线，锥或杆阈值升高，或两者兼而有之。2例患者视网膜电图（ERG）异常。一个有轻度异常的眼电图。1例患者在停止异维甲酸治疗后数月暗适应曲线正常。两名患者在至少一年后出现视锥细胞阈值升高。停止治疗后6个月，1例患者的ERG仍然异常，但在25个月时持续改善明显;第2例患者的ERG在1年时正常。ERG暗视b波刺激-反应曲线的Naka-Rushton参数分析表明，2例患者的反应压缩，最大反应降低。对于一个病人，半饱和常数升高0.7个对数单位，提示视网膜敏感性降低，可能是由于视网膜色素浓度降低。我们怀疑异维A酸可能完成细胞表面或转运分子上的正常视黄醇结合位点。目前正在进行一项前瞻性研究，以确定临床上可测量的对视网膜功能的不良影响是否更常见。
Three of 50 patients treated with isotretinoin (1 mg/kg/day) for cystic acne complained of poor night vision and/or excessive glare sensitivity. While still receiving the drug or shortly thereafter, two patients were found to have abnormal dark-adaptation curves, with elevations of either cone or rod thresholds, or both. Two patients had abnormal electroretinograms (ERGs). One had a mildly abnormal electro-oculogram. The dark-adaptation curves were normal for one patient several months after isotretinoin therapy was discontinued. Two patients had elevated cone thresholds at least one year later. Six months following cessation of therapy, the ERG was still abnormal for one patient, but continued improvement was evident at 25 months; for the second patient, the ERG was normal at one year. Analysis of Naka-Rushton parameters for the ERG scotopic b-wave stimulus-response curves indicated response compression for two patients, as evidenced by a reduction in the maximum response. For one patient, the half-saturation constant was elevated 0.7 log units, suggesting reduction of retinal sensitivity, perhaps from decrease in retinal photopigment concentration. We suspect that isotretinoin may complete for normal retinol binding sites on cell surfaces or transport molecules. A prospective study is currently underway to determine if a clinically measurable adverse effect on retinal function is seen with greater frequency.
乙酸视黄酯对大鼠肝脏和乳腺肿瘤组织中酰基辅酶A：视黄醇酰基转移酶的增强作用以及N-(4-羟苯基)视黄酰胺对其的竞争性抑制作用。
DOI：
10.1016/0006-291x(85)91636-5
发表时间：
1985
影响因子：
3.1
作者：
Ball,MD;Furr,HC;Olson,JA
通讯作者：
Olson,JA