Intraobserver and interobserver variability in GTV delineation on FDG-PET-CT images of head and neck cancers
Intraobserver and interobserver variability in GTV delineation on FDG-PET-CT images of head and neck cancers
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DOI：
10.1016/j.ijrobp.2006.12.039
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发表时间：
2007-07-01
影响因子：
7
通讯作者：
Waldron, John
中科院分区：
文献类型：
--
作者：
Breen, Stephen L.;Publicover, Julia;Waldron, John
目的：为了确定是否增加氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）数据的变化原发部位总肿瘤体积（GTV）在头和颈部cancers.Methods和材料：计算机断层扫描（CT），对比增强CT，FDG-PET-CT扫描获得10例头颈部癌症。8名经验丰富的观察员（6名头颈部肿瘤学家和2名神经放射科医生）可访问临床和放射学报告，概述了每种模式的原发部位GTV。三个病例进行了两次重新轮廓，以评估观察者内变异性。比较了GTV的大小。观察者内和观察者间的变异性通过双向重复测量方差分析进行评估。间和观察者内的可靠性calculated.Results：有没有显着差异，在GTV跨图像模式相比，作为合奏平均值; Wilcoxon匹配对符号秩检验表明，CT体积大于PET-CT。观察员表现出最大的一致性，最可互换的对比增强CT，他们执行不太可靠的PET-CT.Conclusions：除了PET-CT的原发部位GTV划定的头部和颈部癌症不改变体积的GTV定义的这组专家观察员在此患者样本。FDG-PET可以显示颈部淋巴结勾画和其他疾病部位的差异。(c)2007爱思唯尔公司
Purpose: To determine if the addition of fluorodeoxyglucose positron emission tomography (FDG-PET) data changes primary site gross tumor volumes (GTVs) in head and neck cancers.Methods and Materials: Computed tomography (CT), contrast-enhanced CT, and FDG-PET-CT scans were obtained in 10 patients with head and neck cancers. Eight experienced observers (6 head and neck oncologists and 2 neuro-radiologists) with access to clinical and radiologic reports outlined primary site GTVs on each modality. Three cases were recontoured twice to assess intraobserver variability. The magnitudes of the GTVs were compared. Intra- and interobserver variability was assessed by a two-way repeated measures analysis of variance. Inter- and intraobserver reliability were calculated.Results: There were no significant differences in the GTVs across the image modalities when compared as ensemble averages; the Wilcoxon matched-pairs signed-rank test showed that CT volumes were larger than PET-CT. Observers demonstrated the greatest consistency and were most interchangeable on contrast-enhanced CT; they performed less reliably on PET-CT.Conclusions: The addition of PET-CT to primary site GTV delineation of head and neck cancers does not change the volume of the GTV defined by this group of expert observers in this patient sample. An FDG-PET may demonstrate differences in neck node delineation and in other disease sites. (c) 2007 Elsevier Inc.