A comparative study of experimental bilharziasis in monkeys contrasted with the hitherto described lesions in man
A comparative study of experimental bilharziasis in monkeys contrasted with the hitherto described lesions in man
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猴子实验性血吸虫病与迄今为止描述的人类病变的比较研究
DOI：
10.1002/path.1700230308
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
N. Fairley
中科院分区：
文献类型：
--
作者：
N. Fairley
1919年8月和9月，G Lawtoii（1917年）在开罗第三澳大利亚总医院收治的24例早期胆虫病病例中发现了某些模糊的临床症状。感染后4 ~ 12周出现的临床综合征包括发热发作伴腹痛、肝脾肿大、支气管炎、荨麻疹和腹泻。显微镜检查显示高嗜酸性粒细胞和B的侧棘状卵。在接下来的三年中，从第14澳大利亚综合医院收治的患有血吸虫病的大部分病例中获得了病史。我还在B感染的病例中发现了类似的复合体。只有免疫恐惧症。幸运的是，由于暴露于感染的程度有限，没有一例被证明是致命的，因此没有人类病理材料可用于研究。因此，我决定做一个完整的。对发生在实验性感染猴中的早期胆红素血症进行研究，希望由此为这些人类病例中的9例所表现的早期临床表现建立病理学基础。在接下来的两年里（1917年和1918年），25只猴子被实验性地感染了一种或另一种病毒（8只）。ninnsoni或E. kn：mcLtobia），-他们的症状记录，他们的病态
IS the months of August and Septeiiiber 1 9 1 G Lawtoii (1 9 17') noted certain obscnre clinical syiiiptoiiis in twenty-four early cases of biiliarziasis admitted to No. 3 Australian General Hospital, Cairo. The clinical syndrome which supervened four to twelve weelis af ter exposure to infection, consisted of it febrile attack accompanied by abdominal pain, enlarged tender liver and spleen, bronchitis, urticaria and perhaps diarrhea. Microscopical investigation showed both the presence of a high eosinophilin and lateral spined ova of B. mansoizi in the feces.In the following iiionths of the smie year a siniilar history was obtained from a large percentage of cases admitted to the 14th Australian General Hospital suffering from bilharziasis. I also found a similar symptom-complex in cases iufected with B. Immatobia alone. Since, fortunately, owing to the limited iiuuiber of exposures to the infection, none of the cases proved fatal, no human pathological niaterial was available for iiivestigation. I therefore decided to make a completc? study of early biltinrziasis as it occnrred in expeiinientalIy iiifectecl monkeys, hoping thereby to establish a pathological basis for the early clinical picture as manifested in ninny of these human cases. During the snbseqnent two years (1 9 1 7 and 1 9 18) twenty-five monkeys have been experimentally infected with one or other variety (8. ninnsoni or E. kn: mcLtobia),-their symptoms noted, their morbid