Development of galanin- and enkephalin-like immunoreactivities in the sympathoadrenal lineage of the avian embryo - In vivo and in vitro studies
Development of galanin- and enkephalin-like immunoreactivities in the sympathoadrenal lineage of the avian embryo - In vivo and in vitro studies
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DOI：
10.1159/000111229
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发表时间：
1997-07-01
影响因子：
2.9
通讯作者：
GarciaArraras, JE
中科院分区：
文献类型：
--
作者：
BarretoEstrada, JL;MedinaVera, L;GarciaArraras, JE
交感肾上腺神经系统的神经化学分化已被分析集中在两个神经肽，甘丙肽和脑啡肽的发育表达。这两种肽在交感神经节和肾上腺形成的早期表达。肾上腺中的表达在胚胎发育至孵化期间持续存在，而交感神经中的表达随着成交感神经细胞分化成神经元而丧失。甘丙肽的表达和神经生长因子（NGF）和地塞米松（Dex）的调制也在体外进行了研究。这些因素的不同影响被发现肾上腺与交感神经文化。然而，结果与诱导神经元特性（NGF）或嗜铬细胞特性（Dex）的因素的拟议作用相吻合。
The neurochemical differentiation of the sympathoadrenal nervous system has been analyzed by focusing on the developmental expression of two neuropeptides, galanin and enkephalin. Both peptides are expressed early in the formation of the sympathetic ganglia and adrenal gland. Expression in the adrenal persists during embryogenesis to hatching while expression in the sympathetic is lost as sympathoblasts differentiate into neurons. Galanin expression and its modulation by nerve growth factor (NGF) and dexamethasone (Dex) was also studied in vitro. Differential effects of these factors were found on adrenal versus sympathetic cultures. However, the results coincided with the proposed role of the factors in inducing either neuronal properties (NGF) or chromaffin characteristics (Dex).