The thrifty phenotype hypothesis and hearing problems
The thrifty phenotype hypothesis and hearing problems
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DOI：
10.1136/bmj.327.7425.1199
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发表时间：
2003-11-22
影响因子：
--
通讯作者：
Dahlgren, J
中科院分区：
文献类型：
--
作者：
Barrenäs, ML;Bratthall, Å;Dahlgren, J
While looking for solutions to sensorineural hearing loss (SNHL) induced by age or noise, a serious incurable health problem, we became interested in the thrifty phenotype hypothesis because diseases related to this hypothesis are sometimes those linked to SNHL. 1 According to the hypothesis, events during fetal life, such as malnutrition, may cause disease in adulthood. The malnourished fetus makes metabolic adaptations, which may become permanently programmed, persisting throughout life and causing disease later in life. For example, cardiovascular disease, 2 hypertension, obesity, and hypercholesterolaemia are related to reduced fetal growth as reflected by a reduced birth size and to SNHL.
