DISRUPTIVE EFFECTS OF RAPID EYE MOVEMENT SLEEP DEPRIVATION ON LONG-TERM MEMORY
DISRUPTIVE EFFECTS OF RAPID EYE MOVEMENT SLEEP DEPRIVATION ON LONG-TERM MEMORY
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DOI：
10.1016/0031-9384(71)90155-7
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发表时间：
1971-01-01
影响因子：
2.9
通讯作者：
FISHBEIN, W
中科院分区：
文献类型：
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作者：
FISHBEIN, W
睡眠与非常活跃的内源性神经（化学和电）过程有关，这一事实表明，这些过程可能与维持长期记忆储存有关。本实验旨在检验快速眼动（REM）睡眠剥夺会导致长期记忆受损的假设。连续3、5或7天被剥夺快速眼动睡眠的小鼠，在一次抑制性回避训练经历和随后的记忆保留测试之间的间隔，在快速眼动剥夺结束后30分钟或3小时进行测试时，表现出暂时的逆行性遗忘。如果在快速眼动睡眠剥夺间隔后立即进行电休克，小鼠不会从失忆中恢复过来。在进一步的研究中，通过在黑白t迷宫的辨别训练实验和随后的记忆保留测试之间的间隔剥夺小鼠的快速眼动睡眠，获得了这些发现的普遍性。
The fact that sleep is associated with very active endogenous neural (chemical and electrical) processes, suggests that these processes may be involved in the maintenance of long-term memory storage. The present experiments were designed to examine the hypothesis that rapid eye movement (REM) sleep deprivation will produce impairment of long-term memory. Mice deprived of REM sleep for 3, 5 or 7 continuous days, during the interval between a one-trial inhibitory avoidance training experience and a subsequent retention test, displayed a temporary retrograde amnesia when tested 30 min or three hr following termination of REM deprivation. The mice did not recover from the amnesia if electroconvulsive shock was administered immediately following the interval of REM sleep deprivation. In a further study, the generality of these findings was obtained by depriving mice of REM sleep during the interval between a discrimination training experiment in a black-white T-maze and the subsequent retention test.