ENTHALPY-ENTROPY COMPENSATION IN HYDROPHOBIC INTERACTION CHROMATOGRAPHY
ENTHALPY-ENTROPY COMPENSATION IN HYDROPHOBIC INTERACTION CHROMATOGRAPHY
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疏水相互作用色谱中的熵补偿
DOI：
10.1021/jp952285l
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
C. Horváth
中科院分区：
文献类型：
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作者：
Anant Vailaya and;C. Horváth
热力学量和分子结构之间的放热关系被用来促进焓-熵补偿（EEC）的分子解释。对于疏水相互作用的补偿温度TC表示的焓和熵的变化，每单位非极性表面积的分子，它的结论是，TC作为诊断工具的机械身份的过程依赖于这个简单的依赖TC分子参数。而经典的EEC观察到的过程中只涉及没有热容量的变化和TC的评估从线性焓与熵图的斜率在任何温度下测量的数据，这项调查表明，即使当热容量的变化是有限的和恒定的或随温度线性变化，EEC可以发生的过程，如果他们受到相同的机制在一个固定的温度。补偿温度随实验温度的变化而变化。
Exothermodynamic relationships between thermodynamic quantities and molecular structure are employed to facilitate a molecular interpretation of enthalpy−entropy compensation (EEC). For hydrophobic interactions the compensation temperature TC is expressed in terms of the enthalpy and entropy change, both per unit nonpolar surface area of the molecules, and it is concluded that the utility of TC as a diagnostic tool for the mechanistic identity of processes rests on this simple dependence of TC on molecular parameters. Whereas classical EEC is observed only with processes involving no heat capacity change and TC is evaluated from the slopes of linear enthalpy versus entropy plots of data measured at any temperature, this investigation shows that even when the heat capacity change is finite and constant or varies linearly with the temperature, EEC can occur with processes if they are subject to the same mechanism at a fixed temperature. In turn, the compensation temperature changes with the experimental tem...