The T-box transcription factor T-bet in immunity and autoimmunity.
The T-box transcription factor T-bet in immunity and autoimmunity.
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DOI：
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发表时间：
2006-04
影响因子：
24.1
通讯作者：
S. Peng
中科院分区：
文献类型：
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作者：
S. Peng
T-box转录因子T-bet（Tbx 21）已成为1型样免疫的关键调节因子，在T和B淋巴细胞以及树突状细胞和自然杀伤细胞中效应细胞命运的建立和/或维持中起关键作用。几种自身免疫性疾病，特别是那些传统上认为与辅助性T细胞1（Th 1）免疫相关的疾病，似乎需要T-bet，至少在小鼠模型中是如此。本文综述了目前对T-bet在免疫中的作用的认识，以及其在自身免疫中的重要性，并对治疗干预产生影响。
The T-box transcription factor T-bet (Tbx21) has emerged as a key regulator of type 1-like immunity, playing critical roles in the establishment and/or maintenance of effector cell fates in T and B lymphocytes, as well as dendritic cells and natural killer cells. Several autoimmune diseases, especially those classically considered related to T helper 1 (Th1) immunity, appear to require T-bet, at least as judged in mouse models. This review summarizes a current understanding of T-bet's role in immunity, as well as its importance in autoimmunity, with implications for therapeutic intervention.