Increased serum levels of antibodies to Epstein-Barr virus in adults with history of atopic dermatitis.
Increased serum levels of antibodies to Epstein-Barr virus in adults with history of atopic dermatitis.
复制标题
有特应性皮炎病史的成年人血清中 Epstein-Barr 病毒抗体水平升高。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
Ö. Strannegård
中科院分区：
文献类型：
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作者：
I. Rystedt;I. Strannegård;Ö. Strannegård
对140例活动期或治愈期特应性皮炎（AD）患者和48例正常人进行了EB病毒（EBV）、水痘带状疱疹病毒（VZV）和单纯疱疹病毒（HSV）血清抗体检测。AD患者的EBV抗体滴度显著高于对照组，无论AD在采血时是否处于活动期或愈合期。在AD患者与哮喘和/或花粉热和那些没有这些额外的特应性表现之间没有观察到EBV抗体滴度的差异。EBV抗体滴度与血清IgE水平无相关性。AD患者的血清阳性率和抗VZV和HSV抗体滴度与对照组无显著差异。EB病毒抗体滴度的增加可能反映了AD的基本免疫调节紊乱，但也可能是EB病毒在特应性疾病的发病机制中发挥作用。
Serum antibodies to Epstein-Barr virus (EBV), varicella-zoster (VZV) and herpes simplex virus (HSV) were determined in 140 patients with active or healed atopic dermatitis (AD) and 48 control individuals. Antibody titers against EBV were significantly higher in AD patients than in the controls irrespective of whether the AD was active or healed at the time of blood sampling. No difference in EBV antibody titers were observed between AD patients with asthma and/or hay fever and those without such additional atopic manifestations. There was no correlation between EBV antibody titers and serum IgE levels. The frequency of seropositivity and the magnitude of antibody titers against VZV and HSV in AD patients were not significantly different from the controls. Increase in EBV antibody titers may reflect basic immunoregulatory disturbances in AD but it is also possible that EBV may play a role in the pathogenesis of atopic disease.