Omega-3 Polyunsaturated Fatty Acids and Cancer
Omega-3 Polyunsaturated Fatty Acids and Cancer
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DOI：
10.2174/18715206113139990319
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发表时间：
2013-10-01
影响因子：
2.8
通讯作者：
Lim, Kyu
中科院分区：
文献类型：
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作者：
Jing, Kaipeng;Wu, Tong;Lim, Kyu
虽然ω-3多不饱和脂肪酸（ω-3脂肪酸），特别是二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的抗癌作用一直是深入研究的主题，但我们对ω-3脂肪酸抗癌的潜在机制的理解仍然有限。最近的研究描述了EPA和DHA的癌症保护作用，引发了人们对使用这些脂肪酸预防和治疗癌症的新兴趣。在这里，我们总结了omega-3脂肪酸在癌症的发生和发展中的重要性，并回顾了EPA和DHA被认为在癌症发展过程中具有抗癌活性的复杂机制。它的结论是，ω-3脂肪酸可以发挥其抗癌作用，通过影响多个目标涉及癌症发展的各个阶段，包括细胞增殖，细胞存活，血管生成，炎症，转移和表观遗传异常，是至关重要的癌症的发病和进展。
While the anticancer effect of omega-3 polyunsaturated fatty acids (omega-3 fatty acids), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been the subject of intense study, our understanding regarding the underlying mechanisms of omega-3 fatty acids against cancer is still limited. Recent studies describing the cancer protective effect of EPA and DHA have sparked a renewed interest in using these fatty acids for cancer prevention and treatment. Here, we summarize the significance of omega-3 fatty acids in the initiation and progression of cancer, and review the complex mechanisms by which EPA and DHA are thought to have anticancer activities during cancer development. It is concluded that omega-3 fatty acids may exert their anticancer actions by influencing multiple targets implicated in various stages of cancer development, including cell proliferation, cell survival, angiogenesis, inflammation, metastasis and epigenetic abnormalities that are crucial to the onset and progression of cancer.