Differentiation of the chick retinotectal topographic map by remodeling in specificity and refinement in accuracy
Differentiation of the chick retinotectal topographic map by remodeling in specificity and refinement in accuracy
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DOI：
10.1016/s0165-3806(99)00126-1
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发表时间：
1999-11-18
期刊：
影响因子：
--
通讯作者：
Ichijo, H
中科院分区：
文献类型：
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作者：
Ichijo, H
为了了解视网膜地形图的发展，在小鸡中定量检查地形图的分化。标记的视网膜神经节细胞（RGC）轴突顺行地与局部注射的DiI揭示了相对前后位置的生长锥（GC）上的顶盖作为一个函数的nasotemporal的位置的注射部位在视网膜，这使得图形表示的地图。地形图的描述由两个参数的组合：特异性，这表明RGC机构和他们的GC顶盖上的位置之间的地形关系的严格性，和精度，这表明在顶盖上的GC位移的程度。在胚胎第11天（E11）出现了一个低特异性的粗投影。通过E13将初始粗投影重构为具有高特异性的不准确图;此后，通过E15将其细化为具有更高特异性的准确图。研究结果表明，地形图的引导机制是通过粗投影的形成、特异性的重塑和精确性的细化，逐步完成的。(C)1999年由Elsevier Science B. V.出版，版权所有。
To understand the development of the retinotopic map, differentiation of the topographic map was quantitatively examined in the chick. Labeling the retinal ganglion cell (RGC) axons anterogradely with the local injections of DiI revealed the relative anteroposterior positions of their growth cones (GCs) on the tecta as a function of the nasotemporal positions of the injected sites in the retinae, which allowed a graphic representation of the map. The topographic map was depicted by combination of two parameters: specificity which indicates strictness of the topographic relationship between locations of the RGC bodies and their GCs on the tectum, and accuracy which indicates an extent of the GC displacement on the tectum. A crude projection with low specificity emerged at embryonic day 11 (E11). The initial crude projection was remodeled into the inaccurate map with high specificity by E13; thereafter, it was refined to the accurate map with higher specificity by E15. The results suggest that the elements of the guidance mechanism operate stage by stage through the formation of the crude projection, the remodeling in specificity, and the refinement in accuracy to establish the final topographic map. (C) 1999 Published by Elsevier Science B.V. All rights reserved.