Isologous diversification: A theory of cell differentiation
Isologous diversification: A theory of cell differentiation
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DOI：
10.1016/s0092-8240(96)00044-4
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发表时间：
1997-01-01
影响因子：
3.5
通讯作者：
Yomo, T
中科院分区：
文献类型：
--
作者：
Kaneko, K;Yomo, T
基于模拟细胞与生化网络的相互作用和某些化学品消耗后的细胞分裂过程，提出了细胞分化的同源多样化理论。根据基于相互作用的动态系统模型的仿真，提出了以下细胞分化的场景。(1)到一定的阈值数目，分裂产生的细胞几乎完全相同，具有同步的生化振荡。(2)随着数目的增加，振荡失去同步性，导致细胞群具有不同的振荡阶段。(3)不同细胞群的振荡幅度和平均化学成分开始不同。状态的分化行为被传递给子细胞。(4)形成递归性，以致子细胞保持相同的化学性质。这种“记忆”是通过传递初始条件来实现的。(5)连续分化过程。对肿瘤细胞形成机制、干细胞来源、移植异常分化、细胞凋亡等细胞分化过程进行了讨论，并提出了一些新的预测。(C)1997年数学生物学会
An isologous diversification theory for cell differentiation is proposed, based on simulations of interacting cells with biochemical networks and the cell division process following consumption of some chemicals. According to the simulations of the interaction-based dynamical systems model, the following scenario of the cell differentiation is proposed. (1) Up to some threshold number, divisions bring about almost identical cells with synchronized biochemical oscillations. (2) As the number is increased, the oscillations lose synchrony, leading to groups of cells with different phases of oscillations. (3) Amplitudes of oscillation and averaged chemical compositions start to differ by groups of cells. The differentiated behavior of states is transmitted to daughter cells. (4) Recursivity is formed so that the daughter cells keep the identical chemical character. This ''memory'' is made possible through the transfer of initial conditions. (5) Successive differentiation proceeds.The mechanism of tumor cell formation, origin of stem cells, anomalous differentiation by transplantations, apoptosis and other features of cell differentiation process are also discussed, with some novel predictions. (C) 1997 Society for Mathematical Biology