Liquefaction of viscous purulent exudates by deoxyribonuclease.
Liquefaction of viscous purulent exudates by deoxyribonuclease.
复制标题
脱氧核糖核酸酶液化粘性脓性渗出物。
DOI：
10.1016/s0140-6736(50)91676-x
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发表时间：
1950
期刊：
影响因子：
168.9
通讯作者：
J. White
中科院分区：
文献类型：
--
作者：
J. B. Armstrong;J. White
本文描述了粘稠脓痰的一些细胞化学特征，其中脱氧核糖核蛋白原纤维是重要成分。用脱氧核糖核酸酶（一种从牛胰腺中分离的酶）处理这种痰液，减少了这些纤维的数量，使痰液粘度降低。一种方法喷雾吸入这种酶描述了慢性胸部感染的患者。含5 mg的重复吸入获得了临床获益。脱氧核糖核酸酶临床研究中未出现毒性或过敏反应。
Some of the cytochemical characteristics of viscous purulent sputum are described, deoxy-ribonucleoprotein fibrils being an important constituent. Treatment of such sputum with deoxyribonuclease, an enzyme isolated from ox pancreas, reduced the number of these fibrils and made the sputum less viscous. A method of spray inhalation of this enzyme is described for patients with chronic chest infection. Clinical benefit was obtained with repeated inhalations containing 5 mg. of deoxyribonuclease a day. No toxic or anaphylactic reaction was encountered in the clinical studies.