Real-time fluorescence image-guided oncologic surgery.
Real-time fluorescence image-guided oncologic surgery.
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DOI：
10.1016/b978-0-12-411638-2.00005-7
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发表时间：
2014
影响因子：
--
通讯作者：
Achilefu, Samuel
中科院分区：
文献类型：
--
作者：
Mondal, Suman B.;Gao, Shengkui;Zhu, Nan;Liang, Rongguang;Gruev, Viktor;Achilefu, Samuel
医学成像在癌症诊断和规划中起着至关重要的作用。这些患者中的许多人依赖于手术干预的治愈效果。这需要仔细识别原发性和显微镜下肿瘤，并完全切除癌症。尽管已经努力使传统的成像模态适应于术中图像引导，但是它们受到若干限制，诸如大的硬件占用空间、高的操作成本和手术工作流程的中断。由于图像采集的容易性、相对低成本的设备和直观的操作，光学成像方法已经在实时图像引导手术中得到了极大的兴趣。为了在组织自发荧光的低干扰下提高成像深度，这些应用中的许多应用利用人眼不可见的近红外（NIR）波长的光。随着肿瘤亲和造影剂的广泛选择、成像传感器、电子和光学设计的进步，外科医生能够将NIR光学成像技术的不同属性联合收割机结合起来，以改善治疗效果。各种商业和实验性图像引导系统的出现，其处于临床转化的各个阶段，证明了术中光学成像方法在提高肿瘤手术速度的同时具有高准确性和最小边缘阳性的潜在高影响。
Medical imaging plays a critical role in cancer diagnosis and planning. Many of these patients rely on surgical intervention for curative outcomes. This requires a careful identification of the primary and microscopic tumors, and the complete removal of cancer. Although there have been efforts to adapt traditional imaging modalities for intraoperative image guidance, they suffer from several constraints such as large hardware footprint, high operation cost, and disruption of the surgical workflow. Because of the ease of image acquisition, relatively low cost devices and intuitive operation, optical imaging methods have received tremendous interests for use in real-time image-guided surgery. To improve imaging depth under low interference by tissue autofluorescence, many of these applications utilize light in the near-infra red (NIR) wavelengths, which is invisible to human eyes. With the availability of a wide selection of tumor-avid contrast agents, advancements in imaging sensors, electronic and optical designs, surgeons are able to combine different attributes of NIR optical imaging techniques to improve treatment outcomes. The emergence of diverse commercial and experimental image guidance systems, which are in various stages of clinical translation, attests to the potential high impact of intraoperative optical imaging methods to improve speed of oncologic surgery with high accuracy and minimal margin positivity.