Hedgehog Signalling in Development of the Secondary Palate
Hedgehog Signalling in Development of the Secondary Palate
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DOI：
10.1159/000337543
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发表时间：
2012-01-01
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影响因子：
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通讯作者：
Green, Jeremy B. A.
中科院分区：
文献类型：
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作者：
Cobourne, Martyn T.;Green, Jeremy B. A.
Sonic Hedgehog (Shh) 基因编码一种分泌信号分子，该分子在脊椎动物发育的许多方面发挥着重要作用。在发育中的上颚中，Shh 在口腔表面的上皮细胞中强烈表达，表现为一系列与未来的腭皱相对应的条纹。现在有充分的证据表明，Shh 参与了正常腭发育过程中上皮和间质之间发生的许多信号相互作用。特别是，能够在前腭间充质中诱导 Fgf10，而 Fgf10 通过 Fgfr2 能够在上皮细胞中诱导 Shh。这些相互作用对该地区的正常增长和发展至关重要；在缺乏正常的“嘘”信号传导的情况下，小鼠会出现次级腭裂。第二腭的生长和图案密切相关，在中腭生长区内形成连续的皱褶。嘘在这个早期模式形成过程中沿着第二腭的前后轴也起着关键作用。具体来说，在反应扩散机制中充当抑制剂，负责建立皱褶的主要结构。版权所有 (C) 2012 S. Karger AG，巴塞尔
The Sonic hedgehog (Shh) gene encodes a secreted signalling molecule that plays an important role during numerous aspects of vertebrate development. In the developing palate, Shh is strongly expressed in the epithelium on the oral surface, in a series of stripes corresponding to the future rugae palatini. There is now good evidence that Shh is involved in a number of signalling interactions that take place between the epithelium and mesenchyme during normal palatogenesisis. In particular, being able to induce Fgf10 in mesenchyme of the anterior palate which, via Fgfr2, is able to induce Shh in the epithelium. These interactions are essential for normal growth and development of this region; in the absence of normal Shh signalling, mice develop a cleft of the secondary palate. Growth and patterning of the secondary palate are closely linked, with successive rugae forming within a mid-palatal growth zone. Shh also plays a key role during this early patterning process, along the anteroposterior axis of the secondary palate. Specifically, acting as an inhibitor within a reaction-diffusion mechanism that is responsible for establishing primary architecture of the rugae. Copyright (C) 2012 S. Karger AG, Basel